Notably, these attributes do not seem to be a class effect
of DHODH inhibitors.
"Although several antiepileptic drugs have been associated with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the class effect
and impact of other AEDs are not well described," Eric P.
This synergy appears to be a class effect
with all PARPi.
"Further research is needed to determine whether PI-based regimens, either individual regimens or as a class effect
, contribute pathophysiologically to processes leading to worse outcomes in heart failure (e.g., myocardial fat and fibrosis) and whether these findings can be replicated in prospective cohorts," the authors write.
The effect of antidepressant drugs on VTE may be a class effect
and the mechanistic pathways underlying these associations deserve further evaluation, the results showed.
Even admitting a class effect
, they are still unknown mechanisms of interaction that can be the basis of some exceptions.
Similar case reports involving the VEGF-targeting drugs sorafenib (TKI) [6, 10] and bevacizumab (monoclonal antibody) [11, 12] imply a class effect
specific to VEGF.
Recently published studies now suggest a potential class effect
with regards to the cardiovascular and renal outcomes with SGLT2 inhibitors.
The only study till date seeking a true association between CCBs and purpura and bleeding included 19 patients on CCBs of whom 16 had had either abnormal Hess results or marked acral purpura after a Hess test which led the authors to suggest that the high frequency of purpura shown in their study was a pharmacological class effect
rather than idiosyncratic reaction.
"Rosiglitazone was not associated with an increased risk of bladder cancer in any analysis, suggesting the risk is drug-specific and not a class effect
," they wrote online March 30 in BMJ.
The most studied alpha-blocker has been tamsulosin, although a class effect
has been suggested.
"We did not fmd a class effect
for the various antidepressants.