TUBB3

(redirected from class III beta-tubulin)

TUBB3

A gene on chromosome 16q24.3 that encodes a beta tubulin, which is a major constituent of microtubules. TUBB3 plays a key role in proper axon guidance and maintenance.

Molecular pathology
Defects of TUBB3 cause congenital fibrosis of extraocular muscles type 3A, and cortical dysplasia complex with other brain malformations.
References in periodicals archive ?
Is class III beta-tubulin a predictive factor in patients receiving tubulin-binding agents?
Class III beta-tubulin isotype predicts response in advanced breast cancer patients randomly treated either with single-agent doxorubicin or docetaxel.
Expression of class III beta-tubulin in normal and neoplastic human tissues.
Class III beta-tubulin in human development and cancer.
The seco-taxane IDN5390 is able to target class III beta-tubulin and to overcome paclitaxel resistance.
Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients.
Class III beta-tubulin isotype: a key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology.
Expression of class III beta-tubulin in neuroendocrine tumours of gastrointestinal tract.