TUBB3

(redirected from class III beta-tubulin)

TUBB3

A gene on chromosome 16q24.3 that encodes a beta tubulin, which is a major constituent of microtubules. TUBB3 plays a key role in proper axon guidance and maintenance.

Molecular pathology
Defects of TUBB3 cause congenital fibrosis of extraocular muscles type 3A, and cortical dysplasia complex with other brain malformations.
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References in periodicals archive ?
To determine whether blocking CXCR4 with a specific antagonist induced the NSCs/NPCs differentiation toward neuronal fate, we labeled the primary neurospheres with a neuron-specific class III beta-tubulin ([beta]III tubulin) antibody [32] to study the distribution of neuronal progeny in the proliferative spheres.
Antigenic Characterization of Class III Beta-Tubulin. Class III [beta]-tubulin is a microtubule component that is expressed in neuronal cells.
Class III beta-tubulin is a survival factor able to directly contribute to drug resistance (Cicchillitti et al., 2008).
Proteomic characterization of cytoskeletal and mitochondrial class III beta-tubulin. Mol.
Early born lineage of retinal neurons express class III beta-tubulin isotype.
Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients.
Is class III beta-tubulin a predictive factor in patients receiving tubulin-binding agents?
Expression of class III beta-tubulin in normal and neoplastic human tissues.
Class III beta-tubulin in human development and cancer.