Similarly, the percentage of control cells positive for MHC class II molecule
was 1.9%, which was increased to 12.1% by treatment with 27OHChol.
(2003) Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule
These studies demonstrated that the staphylococcal cell wall components bind to TLR2, which are constitutively expressed on monocyte/macrophages and downregulate their MHC class II molecule
expression [22, 24].
The therapy is a highly selective treatment for MS targeting the major histocompatibility complex (MHC) class II molecule
to regulate T-cell activity.
Structures of an MHC class II molecule
with covalently bound single peptides.
The number of different antigenic peptides that can be presented by a Major Histocompatibility Complex (MHC) Class II molecule
varies greatly from allele to allele.
The MHC class II molecule
plays an important role in this process.
One of the Ii fragments, called 'Ii-Key,' acts on a regulatory site on the MHC class II molecule
and controls the association of that molecule with antigenic peptide fragments.
Destruction occurs when the T cell receptor and co-receptor molecules interact with an autoangtigen present in the binding cleft of an MHC class II molecule
on the surface of host cell tissue.
Eventually, a bit of the foreign protein may reemerge, this time handcuffed to an MHC class II molecule
. The pair acts as a red flag to other white cells, called T cells, which set off an aggressive immune response.
B cells expressing a BCR specific for an allo-HLA can capture, internalize, and process the whole allo-HLA class II molecule
and then present allo-HLA-derived peptides on the cell surface.
Ababou and coworkers (Ababou et al., 1994; Ababou et al., 1995) reported evidence for the expression of a third class II molecule
that is cross-reactive with HLA-DP.