Similarly, the percentage of control cells positive for MHC class II molecule
The therapy is a highly selective treatment for MS targeting the major histocompatibility complex (MHC) class II molecule
to regulate T-cell activity.
The number of different antigenic peptides that can be presented by a Major Histocompatibility Complex (MHC) Class II molecule
varies greatly from allele to allele.
The MHC class II molecule
plays an important role in this process.
One of the Ii fragments, called 'Ii-Key,' acts on a regulatory site on the MHC class II molecule
and controls the association of that molecule with antigenic peptide fragments.
Destruction occurs when the T cell receptor and co-receptor molecules interact with an autoangtigen present in the binding cleft of an MHC class II molecule
on the surface of host cell tissue.
Eventually, a bit of the foreign protein may reemerge, this time handcuffed to an MHC class II molecule
1995) reported evidence for the expression of a third class II molecule
that is cross-reactive with HLA-DP.
Activation of T cells requires the recognition via their T-cell receptors of linear peptide antigens presented in the context of a cell-surface human leukoctye antigen (HLA) class II molecule
Its extracellular domain binds to major histocompatibility complex (MHC) class II molecules
, which can reinforce the T cell receptor (TCR) to recognize the peptide-MHC class II complexes (Doyle et al.
Polymorphisms associated with HLA class II molecules
, interleukin-10 (IL-10), and tumor necrosis factor-a (TNF-a) also influence to the FVIII inhibitor development (18).
The LAMP sequence causes an antigen, to which it is attached, to be taken up by the lysosomal subcellular compartment of the cell, an action that has been shown to increase presentation on MHC class II molecules
, which in turn, can produce greater CD4+ T-cell responses against the antigen and a more potent and longer lasting overall immune response.