class I molecule

class I molecule

a major histocompatibility complex antigen made up of two noncovalently bonded polypeptide chains, one glycosylated, heavy, and variable with antigen specificity; the other chain is β2-microglobulin.

class I mol·e·cule

(klas mol'ĕ-kyūl)
A major histocompatibility complex antigen made up of two noncovalently bonded polypeptide chains, one glycosylated, heavy, and variable with antigen specificity; the other chain is β2-microglobulin.
References in periodicals archive ?
No significant effect was observed in cultures containing mAb specific for mouse CD8, H-2[A.sup.b], H-2A[[beta].sup.b], H-2E/[[beta].sup.b], or for human MHC class I molecules. Thus, the in vitro response to SRW extract in HLA-DQ6 and HLA-DQ8 transgenic mice is mediated by CD[4.sup.+] HLA-DQ-restricted T cells.
HLA class I molecules are generally involved in the recognition of proteins synthesized within cells and represent a crucial component in the recognition of viruses and intracellular bacteria.
These predictive methods are more successful for class I molecules because of the more rigid requirements for peptide length and anchor residues.