class I antigen


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Related to class I antigen: major histocompatibility complex, HLA complex

class I antigen

Any of the major histocompatibility molecules present on almost all cells except human red blood cells. These antigens are important in the rejection of grafts and transplanted organs.
See also: antigen
References in periodicals archive ?
Lack of Surface HLA Class I Antigen and [[beta].sub.m] Expression and Downregulation of Several Antigen-Processing Machinery (APM) Components by the sHCC29 and sHCC63 Cell Lines.
Lack of [[beta].sub.2]m and HLA Class I Antigen Expression in the Patients' Sarcomatoid HCC Lesions from which the sHCC29 and sHCC63 Cell Lines Originated.
Another approach to the problem is to enhance the immune system's sensitivity to the scarce class I antigens that may be present on malignant cells.
T cells possess HLA Class I antigens, whereas B cells possess both Class I and II HLA antigens.
138 unique epitopes were defined for one or a group of two or more intact HLA class I antigens. 110 unique epitopes were defined by using SA beads (Table 1, partial list; complete table in the supplemental information available online at https://doi.org/10.1155/2017/3406230) assays to test eluted alloantibodies that were adsorbed from human sera onto the surface of mammalian rHLA single antigen cells then eluted, and murine monoclonal antibodies to determine specificity of each antibody.
In the present study we tried to improve the efficiency of this assay by enhancing uptake of HLA class I antigens via targeting of endocytic receptors on either monocytes or moDCs.