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a purine antimetaboliteantineoplastic agent administered intravenously in the treatment of hairy cell leukemia.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


(klad-ri-been) ,


(trade name)


Therapeutic: antineoplastics
Pharmacologic: antimetabolites
Pregnancy Category: D


Management of active hairy cell leukemia manifested as anemia, leukopenia, thrombocytopenia, or clinical symptoms.chronic lymphocytic leukemia, chronic myelogenous leukemia, non-Hodgkin's lymphomas, progressive multiple sclerosis.


Inhibits DNA synthesis.

Therapeutic effects

Death of rapidly replicating cells, particularly malignant ones.


Absorption: IV administration results in complete bioavailability.
Distribution: Extensively distributed to body tissues; penetrates into cerebrospinal fluid.
Metabolism and Excretion: Unknown.
Half-life: 3–22 hr.

Time/action profile (noted as effect on peripheral counts)

Plateletsunknownunknown12 days
Absolute neutrophil countunknownunknown5 wk
Hemoglobinunknownunknown8 wk
†Time to normalization of counts


Contraindicated in: Hypersensitivity;Diluent contains benzyl alcohol and should be avoided in patients with known intolerance; Obstetric / Lactation: Pregnancy or lactation.
Use Cautiously in: Active infection;↓ bone marrow reserve;Hepatic or renal impairment; Obstetric: Patients with childbearing potential; Pediatric: Safety not established.

Adverse Reactions/Side Effects

Central nervous system

  • fatigue (most frequent)
  • headache (most frequent)
  • dizziness
  • insomnia
  • malaise
  • weakness

Ear, Eye, Nose, Throat

  • epistaxis


  • abnormal breath sounds (most frequent)
  • cough (most frequent)
  • dyspnea


  • edema
  • tachycardia


  • anorexia (most frequent)
  • diarrhea (most frequent)
  • nausea (most frequent)
  • vomiting (most frequent)
  • abdominal pain
  • constipation


  • rash (most frequent)
  • erythema
  • petechiae
  • pruritis
  • sweating


  • neutropenia
  • anemia (most frequent)
  • thrombocytopenia (most frequent)


  • injection site reactions
  • phlebitis
  • thrombosis


  • arthralgia
  • myalgia


  • chills
  • fever (most frequent)
  • infection (most frequent)
  • trunk pain


Drug-Drug interaction

Additive bone marrow depression may occur with other antineoplastics or radiation therapy.


Intravenous (Adults) Hairy cell leukemia–0.09 mg/kg/day for 7 days.

Availability (generic available)

Injection: 1 mg/mL

Nursing implications

Nursing assessment

  • Monitor for bone marrow depression. Assess for fever, chills, sore throat, and signs of infection. Monitor platelet count throughout therapy. Assess for bleeding (bleeding gums, bruising, petechiae; test stool, urine, and emesis for blood). Avoid administering IM injections and taking rectal temperatures. Apply pressure to venipuncture site for 10 min. Anemia may occur. Monitor for increased fatigue and dyspnea.
  • Monitor IV site for phlebitis.
  • Monitor intake and output. Development of uric acid nephropathy in patients with leukemia and lymphoma may be prevented with adequate oral hydration and allopurinol, if needed.
  • Lab Test Considerations: Monitor CD4 T-lymphocyte count and CD8 T-lymphocyte count before initiation of therapy and periodically during and after therapy. Cladribine causes prolonged depression of CD4 and CD8 lymphocyte subset counts, with recovery taking at least 6–12 mo.
    • Monitor hemoglobin, hematocrit, leukocyte, and platelet counts before and periodically throughout therapy, especially during the first 4–8 wk after treatment. During the first 2 wk after therapy, platelet counts, absolute neutrophil count (ANC), and hemoglobin decrease. Transfusions of platelets and red blood cells may be required. Platelet count, ANC, and hemoglobin usually return to normal levels by day 12, week 5, and week 8, respectively.
    • Monitor renal and hepatic function before and periodically during therapy. May cause nephrotoxicity, resulting in elevated serum creatinine, anuria, and acidosis.
    • Monitor serum uric acid concentrations before and periodically during therapy, especially in patients with high tumor burden. May cause elevated serum and uric acid concentrations. May require alkalinization of the urine.
  • May cause irreversible neurologic toxicity, resulting in motor weakness progressing to paraparesis or quadriparesis with high doses. If symptoms occur, discontinue cladribine. There is no known antidote.

Potential Nursing Diagnoses

Risk for infection (Indications)
Risk for injury (Adverse Reactions)


  • high alert: Fatalities have occurred with chemotherapeutic agents. Before administering, clarify all ambiguous orders; double-check single, daily, and course-of-therapy dose limits; have second practitioner independently double-check original order, calculations, and infusion pump settings.
  • Prepare solution in a biologic cabinet. Wear gloves, gown, and mask while handling IV medication. Discard IV equipment in specially designated containers (see ).
  • Intravenous Administration
  • pH: 5.5–8.0.
  • Continuous Infusion: Diluent: Add the daily dose to 500 mL of 0.9% NaCl for injection. Solution is stable for 24 hr at room temperature or 8 days if refrigerated.
    • May also be prepared as a 7-day solution with bacteriostatic 0.9% NaCl for infusion via Pharmacia Deltec medication cassettes.
  • Rate: Administer as a continuous infusion over 24 hr.
  • Y-Site Compatibility: aminophylline, bumetanide, buprenorphine, butorphanol, calcium gluconate, carboplatin, chlorpromazine, cisplatin, cyclophosphamide, cytarabine, dexamethasone, diphenhydramine, dobutamine, dopamine, doxorubicin hydrochloride, droperidol, enalaprilat, etoposide, famotidine, furosemide, granisetron, haloperidol, heparin, hydrocortisone, hydromorphone, idarubicin, leucovorin, lorazepam, mannitol, meperidine, mesna, methylprednisolone, metoclopramide, mitoxantrone, morphine, nalbuphine, ondansetron, paclitaxel, potassium chloride, prochlorperazine, promethazine, ranitidine, sodium bicarbonate, teniposide, vincristine
  • Additive Incompatiblity: D5W. Do not admix with other medications or solutions.

Patient/Family Teaching

  • Instruct patient to notify health care professional promptly in the event of fever; sore throat; signs of infection; bleeding gums; bruising; petechiae; blood in urine, stool, or emesis; unusual swelling; joint pain; shortness of breath; or confusion. Caution patient to avoid crowds and persons with known infections. Instruct patient to use soft toothbrush and electric razor and to be especially careful to avoid falls. Patients should also be cautioned not to drink alcoholic beverages or to take products containing aspirin or NSAIDs because these may precipitate GI hemorrhage.
  • Advise patient to use nonhormonal contraceptive measures during and for at least 4 mo after completion of therapy and to avoid breastfeeding.
  • Instruct patient not to receive any vaccinations without advice of health care professional.

Evaluation/Desired Outcomes

  • Improvement in hematologic status in patients with leukemia.
Drug Guide, © 2015 Farlex and Partners


An anticancer drug used to treat hairy cell LEUKAEMIA and B cell chronic lymphocytic leukaemia. A brand name is Leustat.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
During ECTRIMS, taking place from September 11-13, 2019, in Stockholm, Sweden, EMD Serono will present 39 abstracts, including new long-term safety and efficacy data on MAVENCLAD (cladribine) tablets and new long-term efficacy data for interferon beta (IFN) therapies, including Rebif (interferon beta-1a).
On July 30, 2018, Merck announced that a resubmission of the New Drug Application for cladribine tablets as a potential treatment for patients with relapsing forms of MS had been accepted for filing by the U.S.
Hence, standard chemotherapy agents, such as chlorambucil, bendamustine, cladribine or fludarabine, etc., are not prescribed as first line therapy as they may affect the stem cells.
The US FDA has approved the company's MAVENCLAD (cladribine) for the treatment of adults with relapsing-remitting disease (RRMS) and active secondary progressive disease (SPMS).
--antimetabolites that incorporate into cellular structures and inhibit the synthesis of nucleic acids leading to cell death (methotrexate, fluorouracil, capecitabine, cytarabine, fludarabine, cladribine, gemcitabine, pemetrexed);
The patient received adjuvant chemotherapy with 5 courses of cladribine and was disease-free for 14 months after which she developed bacteremia due to a polymicrobial biliary infection from a chronic indwelling biliary drain.
The treatment of these patients was basically in accordance with the histiocyte society LCH-III protocol with the treatment of isolated PLCH cases based on chemotherapy.[15] Furthermore, for some refractory patients, cladribine was found to improve respiratory function and reduce the size of cysts, even in patients with advanced disease.[16],[17]
Three appetite, left cycles of cladribine. ptosis, hyperthyreosis, depression.
US pharma group Merck said the UAE Ministry of Health and Prevention has approved the registration of its Mavenclad (cladribine tablets) for the treatment of adult patients with highly active relapsing multiple sclerosis (MS) as defined by clinical or imaging features.
Due to the drug's novel mechanism of action, MAVENCLADA (Cladribine tablets) selectively reconstitutes the immune system with minimal impact on the innate immune system functions, making it the only oral short-course therapy to provide up to four years of disease control with a maximum of 20 days of treatment over the first two years.
CLAG-M is a salvage chemotherapy regimen consisting of cladribine, cytarabine, filgrastim and mitoxantrone that has become the standard of care at many institutions across the U.S.