citrate lyase

cit·rate ly·ase

citrate (pro-3S)-lyase; an enzyme that catalyzes the cleavage of citrate to oxaloacetate and acetate, in the absence of coenzyme A.
References in periodicals archive ?
Inhibition of ATP Citrate Lyase (ACL) by bempedoic acid reduces cholesterol biosynthesis and lowers LDL-C by up-regulating the LDL receptor.
The product is an oral and once-daily ATP Citrate Lyase (ACL) inhibitor, which reduces cholesterol and fatty acid synthesis in the liver.
The agreement combines Esperion Therapeutics' ATP Citrate Lyase, or ACL, inhibitor, bempedoic acid, with Daiichi Sankyo's European commercial capabilities which includes more than 1000 professionals dedicated to the commercialization of cardiovascular products, as well as synergies with their existing portfolio of novel oral anticoagulant and antiplatelet products.
Caralluma extract contains pregnane glycosides which are responsible for blocking the activity of citrate lyase, thus, inhibiting fat synthesis and faster burning of fat.
This once-daily pill works in the liver to prevent cholesterol formation by inhibiting a key enzyme called ATP citrate lyase.
[16] This drug inhibits the enzyme adenosine triphosphate citrate lyase, which results in a decreased production of both cholesterol and TGs.
Garcinia cambogia contains the active ingredient hydroxycitric acid, which is thought to inhibit the body's production of lipids via an enzyme called citrate lyase.
Linari, "Citrate in urine determined with a new citrate lyase method," Clinical Chemistry, vol.
They are supposed to contain 75% hydroxycitric acid, which is said to promote weight loss "because it blocks citrate lyase - the chemical responsible for storing carbohydrates in the body as fat".
Citric acid is eventually converted into fatty acid by the action of an enzyme called ATP citrate lyase, resulting in the accumulation of fat.
Abbreviations: ACL, ATP citrate lyase; AMPK, AMP-activated protein kinase; Acetyl CoA, acetyl coenzyme A; ERK, extracellular signal-regulated kinase; HATs, histone acetyltransferases; HDACs, histone deacetylases; Hif1-[alpha], hypoxia inducible factor 1 alpha; MAT, methionine adenosyltransferase; MAVS; mitochondrial antiviral signaling protein; Met, methionine; mTOR, mechanistic target of rapamycin; NF[kappa]B, nuclear factor kappa B; PARP, poly(ADP-ribose) polymerase 1; SAM, S-adenosylmethionine; TCA, tricarboxylic acid cycle.
Clinical studies on Citrin exhibit that HCA can help to reduce the appetite, promote satiety, help the burning of fat stored in the body, as well as inhibit new fat formation by the unique citrate lyase inhibition of HCA, which competes with citric acid to bind with the citrate lyase enzyme."