cis-platinum


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cisplatin

A chemotherapeutic that forms covalent bonds and crosslinks with DNA, which is used for head and neck, ovarian, testicular, and bladder cancers and lymphomas.

Adverse effects
Nephrotoxicity, nausea, sensory neuropathy.

Management for adverse effects
• Nephrotoxicity: adequate hydration to maintain renal flow and high chloride concentration.
• Nausea: ondansetron, a selective antagonist of serotonin S3 receptors.
• Neuropathy: amifostine, growth factors, glutathione, Org 2766, acetyl-L-carnitine, vitamin E have all been tried; per Cochrane review, none proved effective; more studies are needed.

cisplatin

, cis-platinum (sĭs′plă-tĭn)
A drug used to treat cancers, esp. solid tumors such as testicular and ovarian carcinoma. Common side effects of this drug include severe nausea and vomiting and renal failure.
References in periodicals archive ?
An important observation evident from the review is the potentiation of effects of anti-cancer drugs like cis-platinum by curcumin.
Alcohol Adriamycin Amiodarone Chloramphenicol Cis-platinum Dapsone Diphenylhydantoin Disulfiram (Antabuse) (Dilantin) Glutethimide (Doriden) Gold Hydralazine (Apresoline) Isoniazid (INH) Mega Dose of Vitamin A Mega Dose of Vitamin D Metronidazole (Flagyl) Nitrofurantoin Nitrous Oxide (Furadantin,Macrodantin) (chronic repeated inhalation) Perhexiline (Pexid) Penicillin (Large IV doses only) Pyridoxine (Vitamin B6) Vincristine
Care should be taken when using estimated GFRs based on CrCl algorithms for drug administration, in particular for drugs such as cis-platinum and aminoglycoside antibiotics.