cis-platinum


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cisplatin

A chemotherapeutic that forms covalent bonds and crosslinks with DNA, which is used for head and neck, ovarian, testicular, and bladder cancers and lymphomas.

Adverse effects
Nephrotoxicity, nausea, sensory neuropathy.

Management for adverse effects
• Nephrotoxicity: adequate hydration to maintain renal flow and high chloride concentration.
• Nausea: ondansetron, a selective antagonist of serotonin S3 receptors.
• Neuropathy: amifostine, growth factors, glutathione, Org 2766, acetyl-L-carnitine, vitamin E have all been tried; per Cochrane review, none proved effective; more studies are needed.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

cisplatin

, cis-platinum (sĭs′plă-tĭn)
A drug used to treat cancers, esp. solid tumors such as testicular and ovarian carcinoma. Common side effects of this drug include severe nausea and vomiting and renal failure.
Medical Dictionary, © 2009 Farlex and Partners
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Alcohol Adriamycin Amiodarone Chloramphenicol Cis-platinum Dapsone Diphenylhydantoin Disulfiram (Antabuse) (Dilantin) Glutethimide (Doriden) Gold Hydralazine (Apresoline) Isoniazid (INH) Mega Dose of Vitamin A Mega Dose of Vitamin D Metronidazole (Flagyl) Nitrofurantoin Nitrous Oxide (Furadantin,Macrodantin) (chronic repeated inhalation) Perhexiline (Pexid) Penicillin (Large IV doses only) Pyridoxine (Vitamin B6) Vincristine
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