PPAR[alpha] is mainly expressed in the liver and heart, where it is activated by endogenous activators such as fatty acid derivatives (i.e., eicosanoids, palmitic, oleic, and linoleic acids) or exogenous ligands, such as the Wy14,643 compounds or fibrate drugs (i.e., gemfibrozil, clofibrate, ciprofibrate
, and fenofibrate) .
Medicinal plants, beyond antioxidant activity, have been widely used as lipid-lowering agents [22, 30] and several studies have confirmed this ability [9, 31, 32], as observed for ExCA, which was capable of reducing total serum cholesterol and triglycerides similar to drugs currently used for the treatment of hypercholesterolemia and hypertriglyceridemia, ciprofibrate
and simvastatin, respectively.
leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate
," Thrombosis Research, vol.
Currently, there are six categories of antilipidemic drugs available in the market, namely, HMG-CoA reductase inhibitors (statins), for example, lovastatin; bile acid sequestrants (anion-exchange resins), for example, cholestyramine and colestipol; fabric acid derivatives (fibrates), for example, clofibrate, gemfibrozil, fenofibrate, ciprofibrate
, and bezafibrate; nicotinic acid, for example, niacin; cholesterol absorption inhibitors, for example, ezetimibe; and omega-3-fatty acids (fish oil), for example, Pulse .
Validation of a spectrophotometric method to determine ciprofibrate
content in tablets.
is a drug widely used to control cholesterol; however, it is contraindicated in patients with renal and hepatic disorders .
The compound worked in a similar way to the commercial drug ciprofibrate
, which lowers the 'bad' form of low-density lipoprotein (LDL) cholesterol and tryglicerides, a blood fat linked to heart disease.
injection, to the PPAs, clofibrate (CLO) or the more potent ciprofibrate
(CPR), did not exhibit any changes in hepatic microsomal lauric acid hydroxylase (LA-OHase) activities, although kidney microsomal [omega] and [omega]-6 products were increased significantly.
Effect of ciprofibrate
on fibrinogen synthesis in vitro on hepatoma cells and in vivo in genetically obese Zucker rats.
Rimando and her colleagues found that the triglyceride-lowering ability of pterostilbene rivals that of ciprofibrate
increases paraoxonase activity in patients with metabolic syndrome.