cingulin

cingulin

A rod-shaped homodimeric (108 kD subunits) protein on the cytoplasmic domain of vertebrae tight junctions encoded by CGN on chromosome 1q21. Cingulin is a marker of epithelial differentiation and plays a role in cell proliferation, and in inhibiting Rho signaling.
References in periodicals archive ?
Likely, VEGF administration to human brain endothelial cells increases permeability of the monolayer and downregulates claudin-5 and occludin, but not junctional adhesion molecule-1 (JAM-1), cingulin, peripheral plasma membrane protein (CASK), or ZO-1 [92].
TJ proteins identified include transmembrane proteins; occludin and claudin, and cytoplasmic plaque proteins; ZO-1, ZO-2, ZO-3, cingulin, and 7H6.