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Pharmacologic class: Histamine2-receptor antagonist
Therapeutic class: Antiulcer drug
Pregnancy risk category B
Competitively inhibits histamine action at histamine2-receptor sites of gastric parietal cells, thereby inhibiting gastric acid secretion
Oral liquid: 200 mg/5 ml, 300 mg/5 ml
Tablets: 200 mg, 300 mg, 400 mg, 600 mg, 800 mg
Indications and dosages
➣ Active duodenal ulcer (short-term therapy)
Adults and children older than age 16: 800 mg P.O. at bedtime, or 300 mg P.O. q.i.d. with meals and at bedtime, or 400 mg P.O. b.i.d. Maintenance dosage is 400 mg P.O. at bedtime.
➣ Active benign gastric ulcer (short-term therapy)
Adults and children older than age 16: 800 mg P.O. at bedtime or 300 mg P.O. q.i.d. with meals and at bedtime
➣ Gastric hypersecretory conditions (such as Zollinger-Ellison syndrome); intractable ulcers
Adults and children older than age 16: 300 mg P.O. q.i.d. with meals and at bedtime
➣ Erosive gastroesophageal reflux disease
Adults and children older than age 16: 1,600 mg P.O. daily in divided doses (800 mg b.i.d. or 400 mg q.i.d.) for 12 weeks
➣ Heartburn; acid indigestion
Adults and children older than age 16: 200 mg (two tablets of over-the-counter product only) P.O. up to b.i.d. Give maximum dosage no longer than 2 weeks continuously, unless directed by prescriber.
• Renal impairment
• Acetaminophen overdose
• Adjunctive therapy in burns
• Barrett's esophagus
• Renal cancer
• Hypersensitivity to drug
• Alcohol intolerance
Use cautiously in:
• renal impairment
• elderly patients
• pregnant or breastfeeding patients.
• Give with meals.
CNS: confusion, dizziness, drowsiness, hallucinations, agitation, psychosis, depression, anxiety, headache
GU: reversible erectile dysfunction, gynecomastia
Drug-drug. Calcium channel blockers, carbamazepine, chloroquine, lidocaine, metformin, metronidazole, moricizine, pentoxifylline, phenytoin, propafenone, quinidine, quinine, some benzodiazepines, some beta-adrenergic blockers (chlordiazepoxide, diazepam, midazolam), sulfonylureas, tacrine, theophylline, triamterene, tricyclic antidepressants, valproic acid, warfarin: decreased metabolism of these drugs, possible toxicity
Drug-diagnostic tests. Creatinine, transaminases: increased levels
Parathyroid hormone: decreased level Skin tests using allergenic extracts: false-negative results (drug should be discontinued 24 hours before testing)
Drug-food. Caffeine-containing foods and beverages (such as coffee, chocolate): increased cimetidine blood level, increased risk of toxicity
Drug-herbs. Pennyroyal: change in formation rate of herb's toxic metabolite
Yerba maté: decreased yerba maté clearance, possible toxicity
Drug-behaviors. Alcohol use: increased blood alcohol level
Smoking: reversed cimetidine effects
• Monitor creatinine levels in patients with renal insufficiency or failure.
• Assess elderly or chronically ill patients for confusion (which usually resolves once drug therapy ends).
• Inform patient with gastric ulcer that ulcer may take up to 2 months to heal. Advise him not to discontinue therapy, even if he feels better, without first consulting prescriber. Ulcer may recur if therapy ends too soon.
• Advise patient not to take over-the-counter cimetidine for more than 2 weeks continuously, except with prescriber's advice and supervision.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, foods, herbs, and behaviors mentioned above.
cimetidine/ci·met·i·dine/ (si-met´ĭ-dēn) a histamine H2 receptor antagonist, which inhibits gastric acid secretion; used as the base or the monohydrochloride salt in the treatment and prophylaxis of gastric or duodenal ulcers, gastroesophageal reflux disease, upper gastrointestinal bleeding, and conditions associated with gastric hypersecretion.
cimetidineTagamet™ Clinical therapeutics An H2-receptor antagonist used to treat peptic ulcer disease Adverse reactions Diarrhea, headache, drowsiness, fatigue, muscle pain, constipation; rarely mental confusion, agranulocytosis, gynecomastia, impotence, allergic reactions, myalgias, tachycardia, arrhythmias, interstitial nephritis, mild ↑ in creatinine. See Histamine receptor antagonists.
cimetidineA histamine H-2 receptor antagonist drug used to limit acid production in the stomach in cases of peptic ulcer. The drug is on the WHO official list. Brand names are Tagamet, Dyspamet, Galenamet, and Zita.
drug class: H2-histamine receptor antagonist;
action: inhibits histamine at H2-histamine receptor site in parietal cells, which inhibits gastric acid secretion;
uses: short-term treatment of duodenal and gastric ulcers by the control of hyperacidity.