The formation of cilia.
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The researchers demonstrated that HYLS1 stably incorporates into centrioles during their assembly, and plays a crucial role in the early step steps of the ciliogenesis pathway.
Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease.
228) Two novel genes in ciliogenesis and cyst formation encode tumor suppressor (pVHL) (240,241) and collectrin, a homologue of angiotensin-converting enzyme 2.
The genetic contributors to NTDs are still poorly understood, but include genes involved in the folic acid pathway, in both fetal and maternal metabolism, and genes coding for many aspects of embryological control such as planar cell polarity and ciliogenesis.
These histological factors included reductions in the number of glandular ostia, an irregular distribution of glandular ostia, incomplete ciliogenesis, and reductions in the ciliated cell ratio.