ciclosporin


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Related to ciclosporin: tacrolimus

ciclosporin (cyclosporine) 

An immunosuppressant used in the treatment of the ocular manifestation of autoimmune diseases, uveitis, scleritis, keratoconjunctivitis sicca, ligneous conjunctivitis, and to prevent rejection of corneal grafts, etc. It is believed to exert its immunosuppressive effect by inhibiting the activation of cytotoxic T-lymphocytes. See immunosuppressants.
References in periodicals archive ?
Another study suggested that for effective immunosuppressive treatment in dogs, the dosage of ciclosporin A requires adjustments in the course of therapy, guided by serum values and the animals age (MORINI et al., 2008).
Ciclosporin administration during pregnancy induces ultrastructural changes on pancreatic beta-cells of newborn rats.
Patients with mild disease usually require only topical treatment however those with moderate to severe disease generally require phototherapy, ciclosporin, methotrexate and acitretin.
Depending on the associated systemic disease, it is not infrequent the need to scale immunosuppressive therapy with cytotoxic (cyclophosphamide) or immunomodulating agents (methotrexate or ciclosporin), in order to halt the systemic and ocular inflammatory process.
ND: not described; gender: M(ale)/F(emale); CS: corticosteroid; CsA: ciclosporin; AZA: azathioprine; CPA: cyclophosphamide; FFP: fresh frozen plasma; PE: plasma exchange; PP: plasmapheresis; BA: bypassing agents, for example, FEIBA (Factor Eight Inhibitor Bypassing Activity) or rFVII (recombinant Factor Seven); MTX: methotrexate; *: our case report.
The specific objectives of the current studies include the following: (1) to study the bidirectional transport characteristics of indole alkaloids between GM extract and GE extract in Caco-2 cells monolayer; (2) to evaluate the effect of GM with or without verapamil (P-gp inhibitor) on transport of indole alkaloids; (3) to investigate the effect of GM in the absence or presence of ciclosporin (P-gp or MRP2 inhibitor) on transport of indole alkaloids.
It was uncovered to stimulate cytochrome P450 enzyme and thus reduce the plasma level of a wide range of conventional drugs including warfarin, voriconazole, verapamil, talinolol, tacrolimus, simvastatin, quazepam, oral contraceptives, omeprazole, nifedipine, midazolam, methadone, mephenytoin, ivabradine, irinotecan, indinavir, imatinib, gliclazide, fexofenadine, erythromycin, digoxin, debrisoquine, ciclosporin, chlorzoxazone, atorvastatin, amitriptyline, and alprazolam [114-116].
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis.
Ciclosporin population pharmacokinetics and Bayesian estimation in thoracic transplant recipients.
Open trial of ciclosporin treatment for Stevens- Johnson syndrome and toxic epidermal necrolysis.
"In my 10 years dialysing at home a new drug called ciclosporin was discovered and I believe this has helped my kidney survive along with the good care of local doctors and the renal team at James Cook University Hospital, Dr Kenward, Dr Patterson and now Dr Wroe."
Methotrexate, ciclosporin and acitretin are commonly used medications for managing psoriasis.