cicatricial pemphigoid


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to cicatricial pemphigoid: Ocular Cicatricial Pemphigoid

cic·a·tri·cial pem·phi·goid

(sik'ă-trish'ăl pem'fi-goyd)
A chronic disease that produces adhesions and progressive cicatrization and shrinkage of the conjunctival, oral, and vaginal mucous membranes.

pemphigoid, cicatricial 

A rare, idiopathic, chronic systemic disease, most commonly of the elderly and characterized by recurrent blisters and bullae of the skin and mucous membranes, with subsequent scarring and shrinkage. The disease may affect only the conjunctiva (ocular pemphigoid). In this case, the clinical picture is a conjunctivitis with hyperaemia, mucous discharge and small vesicles, which on bursting result in ulceration, pseudomembranes, conjunctival subepithelial fibrosis and conjunctival shrinkage. The disease may give rise to adhesion between the palpebral and bulbar conjunctiva (symblepharon), ankyloblepharon, xerophthalmia, keratoconjunctivitis sicca, entropion, trichiasis and dry eye with corneal ulcer. There is pain or irritation and blurred vision. Treatment includes corticosteroids, surgery for entropion and trichiasis, and keratoprosthesis if vision is affected. Syn. benign mucous pemphigoid. See pseudomembranous conjunctivitis; Stevens-Johnson syndrome; ocular ferning test.

be·nign mu·cous mem·brane pem·phi·goid

(bĕ-nin myūkŭs membrān pemfi-goyd)
Blistering disease chiefly involving the subepidermal mucous membranes of mouth and eye (ocular pemphigus); usually chronic, benign, and typically bilateral. Scarring can occur and may lead to progressive shrinkage and tightening of the affected mucous membranes and connective tissues.
Synonym(s): cicatricial pemphigoid, ocular cicatricial pemphigoid.
References in periodicals archive ?
Regarding the cause, bilateral chronic inflammatory diseases (Stevens-Johnson syndrome, cicatricial pemphigoid) were mixed together with congenital bilateral aniridia and posttraumatic unilateral and bilateral ocular burns, making the final conclusion very difficult to be drawn.
Zaltas et al., "Association of DQw7 (DQB1*0301) with ocular cicatricial pemphigoid," Proceedings of the National Academy of Sciences, vol.
Pure ocular cicatricial pemphigoid is a unique clinical and immunopathological entity distinct from bullous pemphigoid and other subsets identified by antigenic specificity of autoantibodies," Archives of Dermatology, vol.
(65.) Bedane C, McMillan JR, Balding SD, et al.: Bullous pemphigoid and cicatricial pemphigoid autoantibodies react with ultrastructurally separable epitopes on the BP180 ectodomain: evidence that BP180 spans the lamina lucida.
1, Medicare will start covering IVIg treatments for certain mucocutaneous blistering diseases, including pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, cicatricial pemphigoid, and epidermolysis bullosa acquisita.
The procedure, performed at the San Raffaele Hospital in Milan, offers new hope to patients whose sight has been impaired by chemical burns, severe microbial infections, Stevens Johnson syndrome, or ocular cicatricial pemphigoid. The technique, devised by Drs.
As a result, activation and differentiation of inflammatory cells such as T lymphocytes, eosinophils or neutrophils are suppressed, which may explain why tacrolimus was also effective in subjects with cicatricial pemphigoid. [18] Although the mechanism of action is similar to cyclosporine, tacrolimus is 10 to 100 times more potent and with better mucosal penetrating properties than cyclosporine.
ABH has to be differentiated from blood dyscrasias (thrombocytopenia, von Willebrand's disease, other coagulopathies and leukemia), immunobullous disorders (bullous pemphigoid, linear IgA disease, cicatricial pemphigoid, and dermatitis herpetiformis), angiomatoid lesions in Osler-Rendu-Weber syndrome.
The pemphigoid-group diseases consist of bullous pemphigoid, childhood bullous pemphigoid, localised bullous pemphigoid, drug-induced pemphigoid, anti p200 pemphigoid, pemphigoid gestationes, pemphigoid nodularis, and cicatricial pemphigoid. In this review, the clinical features of the autoimmune bullous diseases are discussed according to the above mentioned classification.
The differential diagnosis included Behcet's disease, cicatricial pemphigoid, a fixed drug reaction, and allergic contact dermatitis.
* Cicatricial pemphigoid. This condition presents with erosion and scarring of mucous membranes.