chymotrypsinogen


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chymotrypsinogen

 [ki″mo-trip-sin´o-jen]
the inactive precursor of chymotrypsin, the form in which it is secreted by the pancreas.

chy·mo·tryp·sin·o·gen

(kī'mō-trip-sin'ō-jen),
The precursor of chymotrypsin. Converted to π-chymotrypsin by the action of trypsin.

chy·mo·tryp·sin·o·gen

(kī'mō-trip-sin'ō-jen)
The precursor of chymotrypsin. Converted to π-chymotrypsin by the action of trypsin.

chymotrypsinogen

the inactive precursor of CHYMOTRYPSIN.
References in periodicals archive ?
By the present invention, trypsinogen is converted to trypsin and chymotrypsinogen to chymotrypsin by pre-activation to a maximum and is then dried and defatted simultaneously as hereinafter described, while this high enzymatic activity is held substantially without change, to produce highly active raw powders equal in activity to the fresh gland.
The objective of the POP1 joint drug discovery programme is to identify and develop suitable backup compounds to Propanc's lead product candidate PRP, a solution for intravenous administration of a combination of two pancreatic proenzymes trypsinogen and chymotrypsinogen. This programme involves advancing new compounds through a drug screening process, followed by preclinical and early stage clinical development.
aldolase (158 kDa), BSA (67 kDa), ovalbumin (43 kDa), chymotrypsinogen A (25 kDa), myoglobulin (17.6 kDa), ribonuclease A (13.7 kDa), aprotinin (6.5 Da) and vitamin B12 (1.3 kDa) (GE Healthcare), was conducted to determine the molecular mass of the protein.
The column was calibrated with a set of standard proteins: albumin (67 kDa), ovalbumin (43 kDa), chymotrypsinogen (25 kDa), ribonucleaseA(13 kDa) (all GE Healthcare), and aprotinin (6.5 kDa) (Sigma).
Gel filtration on a fast protein liquid chromatography (FPLC)-Superdex 75 column, which had been calibrated with molecular mass markers, including Blue Dextran 2000, aldolase (158 kDa), BSA (67kDa), ovalbumin (43kDa), chymotrypsinogen A (25 kDa), myoglobulin (17.6 kDa), ribonuclease A (13.7 kDa), aprotinin (6.5 Da), and vitamin B12 (1.3 kDa) (GE Healthcare), was conducted to determine the molecular mass of the protein (Wang and Ng 2001b).
The column was calibrated with a set of standard proteins (GE Healthcare): albumin (67 kDa), ovalbumin (43 kDa), chymotrypsinogen (25 kDa), ribonuclease A (13.7 kDa), and aprotinin (6.52 kDa).
PRP is a solution for intravenous administration of a combination of two pancreatic proenzymes trypsinogen and chymotrypsinogen. Progressing towards a first-in-human study, PRP seeks to prevent recurrence and metastasis from solid tumors by targeting and eradicating cancer stem cells.
1 of the Fahie-Wilson article (ribonuclease A, 0.393; chymotrypsinogen A, 0.310; ovalbumin, 0.165) and constructed a new calibration curve ([K.sub.av] vs In [R.sub.s]).
We calibrated the column with ovalbumin ([M.sub.r] 43 000), chymotrypsinogen A ([M.sub.r] 25 000), and ribonuclease A ([M.sub.r] 14 000), all from Amersham Biosciences, using low sample volumes (<1% of column bed volume) for accurate determination of peak elution volumes.
PRP is a solution for intravenous administration of a combination of two pancreatic proenzymes trypsinogen and chymotrypsinogen that seeks to prevent recurrence and metastasis from solid tumors.