chymopapain


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chymopapain

 [ki″mo-pah-pān´]
a proteolytic enzyme from the tropical tree Carica papaya, used in chemonucleolysis of a herniated disk in the lumbar region.

chy·mo·pa·pa·in

(kī'mō-pap-ā'in),
A cysteine proteinase similar to papain in specificity; on rare occasions, it is used to shrink herniated intervertebral discs as an alternative to surgery; used as a meat tenderizer. It is the major endopeptidase of papaya.

chymopapain

(kī′mō-pə-pā′ĭn, -pī′ĭn)
n.
A proteolytic enzyme that is obtained from unripe papaya fruits and is similar to papain. It was formerly used in the United States to treat herniated intervertebral disks.

Chymopapain

An enzyme from the milky white fluid of the papaya, used for medical purposes in chemonucleolysis.
Mentioned in: Chemonucleolysis
References in periodicals archive ?
Incidence and risk factors for latent sensitization to chymopapain: predictive skin-prick tests in 700 candidates for chemonucleolysis.
[29] Ebata, M., Yasunnobu, K, T.,1962, "Chymopapain -1 Isolation and crystallization and preliminary characterization," J.
The main phytochemicals of papaya latex are the proteolytic enzymes, papain and chymopapain (Brocklehurst and Salih, 1984).
Brocklehurst K, Salih E (1984) Fresh non-fruit of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase [OMEGA].
Anti-CD16-bound cells were treated with chymopapain (ChymoCell-T; The Boots Company PLC) at 20 kat units/well for 30 min at room temperature to separate the cells from the antibody.
Cornelia Stockel (Baxter Co., Munich, Germany) for the chymopapain vials.
This cost-effectiveness issue has been examined empirically by Norton (1986), who studied the costs of surgical disc removal by both excision and use of chymopapain (an enzymatic lytic agent) in workers' compensation claimants in Oregon.
This first attempt to define prevalence rates of papain hypersensitivity in people with allergies is significant for its possible relationship to chemonucleolysis--the injection of chymopapain to dissolve herniated lumbar disks.
The latex from unripe papaya fruit contains enzymes papain and chymopapain; other components include a mixture of cysteine endopeptidases, chitinases, and an inhibitor of serine protease.
In 1941, Jansen and Balls first isolated chymopapain from crude papain derived from the papaya fruit.
CHEMONUCLEOLYSIS: With derivation of chymopapain enzyme from papaya fruit in 1940, experiments to use it for scientific benefit were conducted in 1963, Smith et al (1) used its dehydrating effect in treatment of discogenic pain-Injecting the drug into the nucleus pulposus of the painful bulging disc caused the disc to lose its turgidity and shrink as a result of depolymerization of the proteoglycan and glycoprotein molecules in the nucleus pulposus--this 'shrinking effect' causes the disc to reduce in its height and girth, relieving pressure on the traversing neural component-the source of pain.
2 f e rol ular 345 They contain enzymes such as papain and chymopapain to help reduce inflammation.