chymopapain

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chymopapain

[ki″mo-pah-pān´]

a proteolytic enzyme from the tropical tree Carica papaya, used in chemonucleolysis of a herniated disk in the lumbar region.

chy·mo·pa·pa·in

(kī'mō-pap-ā'in),

A cysteine proteinase similar to papain in specificity; on rare occasions, it is used to shrink herniated intervertebral discs as an alternative to surgery; used as a meat tenderizer. It is the major endopeptidase of papaya.

Farlex Partner Medical Dictionary © Farlex 2012

chymopapain

(kī′mō-pə-pā′ĭn, -pī′ĭn)

A proteolytic enzyme that is obtained from unripe papaya fruits and is similar to papain. It was formerly used in the United States to treat herniated intervertebral disks.

Chymopapain

An enzyme from the milky white fluid of the papaya, used for medical purposes in chemonucleolysis.

Mentioned in: Chemonucleolysis

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References in periodicals archive ?

Incidence and risk factors for latent sensitization to chymopapain: predictive skin-prick tests in 700 candidates for chemonucleolysis.

Anaphylaxis to patent blue dye--misadventure or misdemeanour?

[29] Ebata, M., Yasunnobu, K, T.,1962, "Chymopapain -1 Isolation and crystallization and preliminary characterization," J.

Evidence of fibrinolytic protease in the latex of Synadenium grantii Hook 'f'

The main phytochemicals of papaya latex are the proteolytic enzymes, papain and chymopapain (Brocklehurst and Salih, 1984).

Brocklehurst K, Salih E (1984) Fresh non-fruit of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase [OMEGA].

Histaminergic effect of crude papaya latex on isolated guinea pig ileal strips

Anti-CD16-bound cells were treated with chymopapain (ChymoCell-T; The Boots Company PLC) at 20 kat units/well for 30 min at room temperature to separate the cells from the antibody.

Cornelia Stockel (Baxter Co., Munich, Germany) for the chymopapain vials.

Major Interference from Leukocytes in Reverse Transcription-PCR Identified as Neurotoxin Ribonuclease from Eosinophils: Detection of Residual Chronic Myelogenous Leukemia from Cell Lysates by Use of an Eosinophil-depleted Cell Preparation

This cost-effectiveness issue has been examined empirically by Norton (1986), who studied the costs of surgical disc removal by both excision and use of chymopapain (an enzymatic lytic agent) in workers' compensation claimants in Oregon.

The rehabilitation of persons with low back pain

This first attempt to define prevalence rates of papain hypersensitivity in people with allergies is significant for its possible relationship to chemonucleolysis--the injection of chymopapain to dissolve herniated lumbar disks.

Papain allergy and surgical risk

The latex from unripe papaya fruit contains enzymes papain and chymopapain; other components include a mixture of cysteine endopeptidases, chitinases, and an inhibitor of serine protease.

Study of immunomodulatory activity of aqueous extract of Carica papaya in Wistar rats

In 1941, Jansen and Balls first isolated chymopapain from crude papain derived from the papaya fruit.

Current evidence of minimally invasive spine surgery in the treatment of lumbar disc herniations

CHEMONUCLEOLYSIS: With derivation of chymopapain enzyme from papaya fruit in 1940, experiments to use it for scientific benefit were conducted in 1963, Smith et al (1) used its dehydrating effect in treatment of discogenic pain-Injecting the drug into the nucleus pulposus of the painful bulging disc caused the disc to lose its turgidity and shrink as a result of depolymerization of the proteoglycan and glycoprotein molecules in the nucleus pulposus--this 'shrinking effect' causes the disc to reduce in its height and girth, relieving pressure on the traversing neural component-the source of pain.

Interventional techniques for treatment of discogenic pain

2 f e rol ular 345 They contain enzymes such as papain and chymopapain to help reduce inflammation.

5 reasons to eat.. health focus

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