Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on murine heart development: alteration in fetal and postnatal cardiac growth, and postnatal cardiac chronotropy
The primary effect of dexmedetomidine on heart rate is negative chronotropy
, effected by blocking the cardio accelerator nerves as well as by augmenting vagus nerve.
L-NAME in combination with DECC did not change the negative inotropy, negative chronotropy
and the decrease in coronary flow induced by DECC.
2003), negative inotropy and chronotropy
(Radhakrishnan et al.
Mechanistically, peripheral effects of beta blockers on the heart and kidneys lead to decreased chronotropy
and inotropy as well as lower blood pressure.
S-(-)-cathinone and its major metabolite S-(-)-norephedrine caused coronary vasoconstriction, negative inotropy and negative chronotropy
in guinea-pig-isolated perfused hearts (Al-Motarreb & Broadley 2003).
is reported in both human and isolated tissue studies.
CCBs prevent calcium influx into the cell, resulting in a decrease in vascular tone as well as negative cardiac inotropy and chronotropy