References in periodicals archive ?
The many metrics of cardiac chronotropy: A pragmatic primer and brief comparison of metrics.
Therapeutic benefit results from decreased chronotropy and inotropy.
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on murine heart development: alteration in fetal and postnatal cardiac growth, and postnatal cardiac chronotropy. Toxicol Sci 88:242-249.
The primary effect of dexmedetomidine on heart rate is negative chronotropy, effected by blocking the cardio accelerator nerves as well as by augmenting vagus nerve.
L-NAME in combination with DECC did not change the negative inotropy, negative chronotropy and the decrease in coronary flow induced by DECC.
Mechanistically, peripheral effects of beta blockers on the heart and kidneys lead to decreased chronotropy and inotropy as well as lower blood pressure.
S-(-)-cathinone and its major metabolite S-(-)-norephedrine caused coronary vasoconstriction, negative inotropy and negative chronotropy in guinea-pig-isolated perfused hearts (Al-Motarreb & Broadley 2003).
Positive chronotropy is reported in both human and isolated tissue studies.
CCBs prevent calcium influx into the cell, resulting in a decrease in vascular tone as well as negative cardiac inotropy and chronotropy. In situations of overdose, patients may experience vasodilation and bradycardia (slow heart rate) leading to shock.