chronotherapy


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chro·no·ther·ap·y

(kron'ō-thār'ă-pē),
The practice of administering chemotherapy at certain times of the day that are thought to be optimal for enhanced activity or lessened toxicity.
See also: chronooncology.
[chrono- + therapy]
Farlex Partner Medical Dictionary © Farlex 2012

chronotherapy

(krŏn′ō-thĕr′ə-pē, krō′nə-)
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

chronotherapy

Any therapy based on the timing of physiologic and pathologic events.

Alternative medicine
The process in which a person’s daily activities are supposedly synchronised with a natural metabolic rhythm in a 24-hour cycle. Chronotherapy establishes routines of exercise, eating, work, study, rest and sleep.

Oncology
The adminstration of chemotherapy doses synchronised to the body’s circadian rhythm. Chronotherapy may increase allowable doses of chemotherapeutics, while decreasing tumour burden and chemotherapy-related side effects.

Chronotherapeutics, core concepts
▪ Predictable pattern—Bioperiodic variation in manifestations of disease that are common to all individuals.
▪ Individual pattern—Variations in chronokinetics unique to one person.
 
Chronotherapeutics, relevance
▪ Variation in intensity of symptoms over time—e.g., allergic rhinitis, angina, asthma, MI, postsurgical pain, ulcer disease.
▪ Where therapeutic-to-toxic ratio varies predictably—e.g., chemotherapy.
▪ Where pharmacokinetics are known to be biologic rhythm-dependent—e.g., antihistamines, antihypertensives, heparin, NSAIDs.
▪ Where hormonal manipulation is intended to simulate the normal temporal ebb-and-flow hormone levels—e.g., insulin in IDDM, corticosteroid and luteinising hormone-releasing hormone.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

chronotherapy

Any therapy based on the timing of physiologic and pathologic event. See Bright light therapy, Chronobiology, Circadian rhythm, Seasonal affective disorder Oncology The adminstration of chemotherapy doses synchronized to the body's circadian rhythm; CT may ↑ allowable doses of chemotherapeutics, ↓ tumor burden, and chemotherapy-related side effects.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Promised in vitro drug release profiles were achieved by pulsatile technology-based multi-particulates of DC to cater for the needs of chronotherapy of circadian rhythm-based chronic diseases such as RA.
Schachat et al., "Rapid and Sustained Antidepressant Response with Sleep Deprivation and Chronotherapy in Bipolar Disorder," Biological Psychiatry, vol.
On the other hand the study revealed an improved HPA axis responsiveness in patients with RA who were administered prednisolone chronotherapy compared to conventional morning prednisolone treatment25 and this specific effect is the cause of improved symptom control as compared to morning prednisolone.
Doctors are becoming increasingly interested in chronotherapeutic approaches and cancer, as well as other chronic diseases such as rheumatoid arthritis, are promising clinical applications for chronotherapy.
This not only may be an important consideration in regard to timing of AED, identifying and preventing sleep deprivation; this may also raise the possibility of integrating chronotype evaluations and chronotherapy in the comprehensive care of epilepsy patients.
The three forms of chronotherapy can be associated as a triple therapy (6).
Circadian variation of blood pressure: the basis for the chronotherapy of hypertension.
Targeting pathophysiological rhythms: prednisone chronotherapy shows sustained efficacy in rheumatoid arthritis.
In the present study, the two concepts, that is, floating and pulsatile, are combined in order to get gastroretentive floating pulsatile delivery system of lercanidipine HCl, intended for chronotherapy of hypertension.
Ran et al., "Fixed-combination of amlodipine and diuretic chronotherapy in the treatment of essential hypertension: improved blood pressure control with bedtime dosinga multicenter, open-label randomized study," Hypertension Research, vol.