chronic toxicity


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chronic toxicity

Toxicology A condition caused by repeated or long-term exposure to low doses of a toxic substance
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Using LC[(EC).sub.50] values No Observed Effect Concentrations and chronic toxicity units [TU.sub.c] were obtained.
In our proposal, animals belonging to the chronic toxicity and carcinogenicity study arm are observed until 130 weeks of age (corresponding to about 75-80 years of age in humans), starting exposure during fetal life (dams, 12th day of pregnancy), whereas OECD guidelines stipulate that animals should be killed and examined at 104 weeks of treatment (corresponding to about 60-65 years of age in humans) (Huff et al.
Chronic toxicity studies are performed on at least three trophic levels, generally fish, daphnids and algae, and are provided as part of the regulatory filing.
It included acute and chronic toxicity assays, assessment of the benthic macrofauna (numerical density, Shannon Diversity Index, Pielou Evenness Index and deformity of the mentum of Chironomidae sp.) and chemical analysis (chromium concentration in the sediment samples).
During the chronic toxicity study according to the fertility parameter the greatest inhibition of fertility is observed for 27-D compound in constant and single seeding conditions (Figure 1, Figure 2).
Taken together, body weight changes, relative organ weights, hematological and blood chemistry, and histological data indicate that there is no chronic toxicity in rats fed Z.
Fitzhugh, "Chronic toxicity of 2,4-dichlorophenoxyacetic acid in rats and dogs," Toxicology and Applied Pharmacology, vol.
Abstract Arsenic, a naturally occurring metal, is best known as a poison and can generate both acute and chronic toxicity. Exposure can occur through air, water, soil, and food.
The website also says the spraying is not repeated often enough to cause "chronic toxicity."
a one-year chronic toxicity study in an appropriate animal model or a two year carcinogenesis study in rodents;
Mycotoxins-toxic secondary metabolites produced by mycotoxigenic fungi pose a significant risk to the food chain, they may be the most hazardous of all food contaminants in terms of chronic toxicity and legislative limits on their levels in food and feed continue to be developed worldwide, rapid and reliable methods for the determination of both mycotoxigenic fungi and mycotoxins in foods and food are therefore essential.

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