chronic sclerosing sialadenitis

chronic sclerosing sialadenitis

An uncommon unilateral inflammatory condition affecting the submandibular gland, which may mimic neoplasia.
 
Aetiology
Idiopathic, stones, microliths, infection, immune-related, linked to reduced salivary flow, increased viscosity. Long-standing obstruction causes inflammation leading to acinar atrophy and fibrosis. The most extreme manifestation of this process is the so-called Kuttner tumour—a rock-hard, tumour-like areas of end-stage fibrosis and lymphoplasmacytic inflammation, which may be accompanied by metaplasia (squamous, mucous, ciliated, oncocytic) in the ducts.

DiffDx
Lymphoma, lymphoepithelial lesion.
References in periodicals archive ?
Kuttner, a German physician, who described a series of patients with a unilateral, hard, tumour-like mass of submandibular gland, which histologically showed features of chronic sclerosing sialadenitis (1).
DISCUSSION: Kuttner tumour, otherwise known as chronic sclerosing sialadenitis, is a chronic inflammatory disease of the salivary gland characterised by progressive periductal fibrosis, dilated ducts with a dense lymphocyte infiltration and lymphoid follicle formation and acinar atrophy (1).
Chronic Sclerosing Sialadenitis (Kuttner tumour): A Rare Entity Mimicking Malignancy.
Chronic sclerosing sialadenitis of the submandibular gland is mainly due to a T lymphocyte immune reaction.
In addition to the pulmonary lesions, increased numbers of IgG4-positive plasma cells were present in regional nodes and in areas of chronic sclerosing sialadenitis of 1 patient.
INTRODUCTION: Kuttner tumor, also known as chronic sclerosing sialadenitis and also termed as cirrhosis of submandibular gland.
DISCUSION: Chronic sclerosing sialadenitis or Kuttner tumor or cirrhosis of submandibular gland, although one of the common disease affecting submandibular gland, is still underrecognised, with only few publications about this entity in the literature (6,7).
Ochoa, Erin Rubin MD, Harris, et al: Marginal zone B cell lymphoma of salivary gland arising in chronic sclerosing sialadenitis (Kuttner tumor).
Chronic sclerosing sialadenitis often exclusively involves the submandibular gland, occasionally with a bilateral presentation.
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