Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis
He underwent excision of a submandibular gland, and the pathology revealed chronic sclerosing sialadenitis
, with a large subset of inflammatory cells positively staining for IgG4 (Figure 2).
Similarly, the Kuttner's tumor or chronic sclerosing sialadenitis
, characterized by severe swelling of the submandibular glands, was initially considered as an individual disease entity, frequently associated with sclerosing cholangitis and retroperitoneum involvement.
Kuttner, a German physician, who described a series of patients with a unilateral, hard, tumour-like mass of submandibular gland, which histologically showed features of chronic sclerosing sialadenitis (1).
Chronic Sclerosing Sialadenitis (Kuttner tumour): A Rare Entity Mimicking Malignancy.
In addition to the pulmonary lesions, increased numbers of IgG4-positive plasma cells were present in regional nodes and in areas of chronic sclerosing sialadenitis
of 1 patient.
DISCUSION: Chronic sclerosing sialadenitis or Kuttner tumor or cirrhosis of submandibular gland, although one of the common disease affecting submandibular gland, is still underrecognised, with only few publications about this entity in the literature (6,7)., This tumor was first described by Kuttner in 18968.
(1.) Ochoa, Erin Rubin MD, Harris, et al: Marginal zone B cell lymphoma of salivary gland arising in chronic sclerosing sialadenitis (Kuttner tumor).
Chronic sclerosing sialadenitis often exclusively involves the submandibular gland, occasionally with a bilateral presentation.
Kuttner tumor (chronic sclerosing sialadenitis) of the submandibular gland: an underrecognized entity.