chronic sclerosing sialadenitis

chronic sclerosing sialadenitis

An uncommon unilateral inflammatory condition affecting the submandibular gland, which may mimic neoplasia.
 
Aetiology
Idiopathic, stones, microliths, infection, immune-related, linked to reduced salivary flow, increased viscosity. Long-standing obstruction causes inflammation leading to acinar atrophy and fibrosis. The most extreme manifestation of this process is the so-called Kuttner tumour—a rock-hard, tumour-like areas of end-stage fibrosis and lymphoplasmacytic inflammation, which may be accompanied by metaplasia (squamous, mucous, ciliated, oncocytic) in the ducts.

DiffDx
Lymphoma, lymphoepithelial lesion.
References in periodicals archive ?
Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Kuttner's tumor).
He underwent excision of a submandibular gland, and the pathology revealed chronic sclerosing sialadenitis, with a large subset of inflammatory cells positively staining for IgG4 (Figure 2).
Similarly, the Kuttner's tumor or chronic sclerosing sialadenitis, characterized by severe swelling of the submandibular glands, was initially considered as an individual disease entity, frequently associated with sclerosing cholangitis and retroperitoneum involvement.
Kuttner, a German physician, who described a series of patients with a unilateral, hard, tumour-like mass of submandibular gland, which histologically showed features of chronic sclerosing sialadenitis (1).
Chronic Sclerosing Sialadenitis (Kuttner tumour): A Rare Entity Mimicking Malignancy.
In addition to the pulmonary lesions, increased numbers of IgG4-positive plasma cells were present in regional nodes and in areas of chronic sclerosing sialadenitis of 1 patient.
DISCUSION: Chronic sclerosing sialadenitis or Kuttner tumor or cirrhosis of submandibular gland, although one of the common disease affecting submandibular gland, is still underrecognised, with only few publications about this entity in the literature (6,7)., This tumor was first described by Kuttner in 18968.
(1.) Ochoa, Erin Rubin MD, Harris, et al: Marginal zone B cell lymphoma of salivary gland arising in chronic sclerosing sialadenitis (Kuttner tumor).
Chronic sclerosing sialadenitis often exclusively involves the submandibular gland, occasionally with a bilateral presentation.
Kuttner tumor (chronic sclerosing sialadenitis) of the submandibular gland: an underrecognized entity.
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