chronic renal failure


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chronic renal failure (CRF)

gradual loss of kidney function, with progressively more severe renal insufficiency until the stage called chronic irreversible kidney failure or end-stage renal disease. Symptoms may include polyuria, anorexia or nausea, dehydration, and neurological symptoms. See also renal failure.

chronic renal failure

A spectrum of severe renal diseases ranging from non-dialysis-dependent chronic kidney disease in patients don’t require renal replacement therapy (i.e., dialysis or renal transplant), to those with end-stage kidney disease who do.

Aetiology
Diabetes, hypertension, glomerulonephritis.

Clinical findings, external
Dehydration, oedema, anaemia, sallow colour, pruritis, brown discolouration of nails, bruising (abnormal platelets); other findings may include cutaneous vasculitic lesions, diabetes, peripheral vascular disease, spina bifida or other causes of neurogenic bladder.

Clinical findings, internal
Hypertension, heart failure, pulmonary oedema, pleural effusions, pericardial effusion, GI bleeding due to peptic ulceration, gastritis/oesophagitis/colitis, acute pancreatitis.

Cause of death, chronic renal failure
Uraemia:
• Convulsions;
• Coma;
• Cardiac myocyte dysfunction;
• Congestive heart failure;
• Pericarditis;
• Pericardial effusion;
• Arrhythmias;
• Tamponade;
• Left ventricular hypertrophy;
• Coronary artery disease.
Tumours:
• Renal cell carcinoma;
• Lymphomas;
• Hepatocellular carcinoma;
• Thyroid carcinoma.

chronic renal failure

Chronic kidney failure Nephrology A slow decline in renal function, which may be 2º to chronic HTN, DM, CHF, SLE, or sickle cell anemia and, if extreme, leads to ESRD, mandating kidney dialysis; an abrupt decline in renal function may be triggered by acute intercurrent processes–eg, sepsis, shock, trauma, kidney stones, kidney infection, drugs–aspirin or lithium, toxins, abuse substances, or injection of iodinated radiocontrast Lab Fluid retention, uremia Management Low-protein diet to conserve renal function; transplantation if ESRD
References in periodicals archive ?
Patients with chronic renal failure could develop severe thrombocytopenia and platelet dysfunction as well as bleeding.
The risk of hypothyroidism in chronic renal failure is very high if serum creatinine level are above 6mg/dl.
1 in their study on four renal failure groups provide evidence that the progression of the periodontal disease in chronic renal failure patients was correlated with bad oral hygiene.
Three hundred and fifty patients of chronic renal failure were included through non-probability purposive sampling.
She had diabetes mellitus and chronic renal failure and she had been administered high doses of (250 mg/day) fenofibrate without taking renal functions into consideration.
In some cases, little can be done to prolong the life of a cat diagnosed with late-stage chronic renal failure.
Chronic renal failure is usually caused by kidneys getting damaged by an infection or inflammation.
Not only do the results support proceeding with COPD wasting as an indication but these data are promising with respect to other indications associated with chronic wasting such as congestive heart failure or chronic renal failure.
Long-term use of the immunosuppressants cyclosporine or tacrolimus is the primary cause of chronic renal failure, which is characterized by a 30% to 50% decrease in the glomerular filtration rate during the first 6 posttransplant months followed by stabilization or a slower rate of loss of renal function.
There is extra stress on the surviving cells and this leads to more deterioration of the kidneys, called chronic renal failure (CRF).
Both Neulasta and Aranesp have won approval by the European Commission, while Aranesp has also been OK'd in Canada for the treatment of anemia associated with chronic renal failure.
Many factors can affect interpretation of glycohemoglobin (GHB/HbA1c) measurements in patients with chronic renal failure (CRF).

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