chronic pulmonary coccidioidomycosis

chronic pulmonary coccidioidomycosis

Lung infection due to Coccidioides immitis and C posadasii, which are endemic in southwestern US. It affects up to 8% of those exposed to C immitis spores, often after a latency period of up to 20 years.

Clinical findings
Two-thirds of patients are asymptomatic; others exposed develop a mild influenza-like illness 1–4 weeks after exposure, with fever, sore throat, cough, headache, fatigue and pleuritic chest pain. Increased risk of severe disease (e.g., HIV disease), especially with low CD4+ cell counts, pregnancy, lymphoma, organ transplants, prolonged corticosteroid treatment, tumour necrosis factor (TNF)-alpha inhibitor therapy.

Management
Amphotericin B, azoles (e.g., ketoconazole, fluconazole); for those who fail to respond, the options are largely limited to experimental agents.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

chronic pulmonary coccidioidomycosis

Infectious disease Lung infection due to Coccidioides immitis, endemic in southwestern US; it may follow a 20-yr latency period and is more common in immunocompromised hosts. See Coccidioidomycosis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Chronic pulmonary coccidioidomycosis may develop 20 years or more after infection.
The clinical diagnoses according to ICD9 Codes included 105 hospitalizations for pulmonary coccidioidomycosis (114.0, 114.5), one with extrapulmonary coccidioidomycosis (114.1), five with coccidioidal meningitis (114.2), 18 with other forms of coocidioidomycosis (114.3), 19 with chronic pulmonary coccidioidomycosis (114.4), and 33 with unspecified coccidioidomycosis (114.9).
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