chronic neutrophilic leukaemia

chronic neutrophilic leukaemia

A rare myeloproliferative disorder characterised by prominent neutrophilia in peripheral blood, myeloid hyperplasia in the bone marrow, hepatosplenomegaly and an absence of the Philadelphia chromosome or BCR/ABL fusion gene.

Clinical findings
Hepatosplenomegaly; less commonly: pruritus, gout, mucocutaneous bleeding.

DiffDx
CML, neutrophilic-CML, myelodysplastic syndrome.

Management
Hydroxyurea to control leukocytosis and reduce splenomegaly; chemotherapy.

Prognosis
Uncertain; patients die in blast transformation or with progressive leucocytosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The rest 20 cases were chronic cases (36%), of which 17 were CML (30%), which include one case of chronic neutrophilic leukaemia, and 3 were CLL cases (5%).
Cytochemical stains used were profoundly positive, in almost all cases, except in one case of chronic neutrophilic leukaemia. Acute leukaemias were well studied, with the stains, SBB and PAS, and accurately classified as per FAB classification.
Mr Duncan was diagnosed with Chronic Neutrophilic Leukaemia 20 years ago, a rare disorder which has no cure - there are only about 130 cases reported in the world.
Since more than 80% of white cells in blood and marrow were mature neutrophils, the diagnosis of chronic neutrophilic leukaemia was thought of.

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