chronic myeloproliferative disorder


Also found in: Acronyms.

chronic myeloproliferative disorder

A generic term for the autonomous proliferation of myelopoietic stem cells.

Chronic myeloproliferative disorders
• Common—Chronic myeloid leukaemia, polycythemia vera, essential thrombocythemia, chronic idiopathic myelofibrosis.
• Uncommon—Chronic neutrophilic leukaemia, chronic eosinophilic leukaemia/hypereosinophilic syndrome, chronic myeloproliferative disease, unclassifiable.
References in periodicals archive ?
JAK2 mutation has been shown to be associated with a wide spectrum of chronic myeloproliferative disorders (5-9).
JAK2 V617F mutation was detected in 68 per cent (51 of 75) patients with chronic myeloproliferative disorders. The proportion of positive cases per disease subtype ranged from 82 per cent (28 of 34) for PV, 70 per cent (7 of 10) for ET and 52 per cent (16 of 31) for IMF.
Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders. Blood 2003;102:1869-71.
MPL W515L/K mutations in 343 Chinese adults with JAK2V617F mutation-negative chronic myeloproliferative disorders detected by a newly developed RQ-PCR based on TaqMan MGB probes.
Chronic myeloproliferative disorders (MPDs) include polycythemia vera, chronic myelocytic leukemia, essential thrombocythemia, and myelofibrosis with myeloid metaplasia.
Granulocytic sarcoma (GS) is the tumoral infiltration of extramedullary sites with immature myeloid precursor cells; it is associated with 3%-8% of acute myeloid leukemia (AML) cases and rarely with chronic myeloproliferative disorders 11].
To make a definitive diagnosis of Gaucher disease, assays for acid [Beta]-glucosidase activity in white blood cells or fibroblasts must be performed, because Gaucher-like cells may be found in patients with other conditions, such as chronic myeloproliferative disorders, chronic dyserythropoietic anemias, thalassemia, Shwachman syndrome (overloading of normal enzymatic capacity to process normal cell breakdown), or other malignant conditions.[3] Enzyme assays performed on our patient confirmed the diagnosis of Gaucher disease.
Chronic myeloproliferative disorders (CMPDs) are a group of heterogeneous clonal stem cell disorders that can be defined by specific cytomorphological phenotypes and sometimes genetic features (1).

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