chronic lymphocytic leukaemia/small lymphocytic lymphoma
chronic lymphocytic leukaemia/small lymphocytic lymphomaA neoplasm of monomorphic small, round B-cells in the bone marrow, peripheral blood and lymph nodes with prolymphocytes, usually expressing CD5 and CD23. The term small lymphocytic lymphoma (SLL) refers to tissue infiltrates with the morphology and phenotype of CLL, but without known leukaemia (SLL, c/w CLL).
Occurrence 90% of adult leukaemias; usually in the 7th decade.
Bone marrow, blood, lymph nodes (rarely, aleukemic = SLL), spleen, liver.
80% are stage A at presentation; 20% are stage B or C.
Hypogammaglobulinemia, autoimmune, M-component.