chronic myeloid leukaemia

(redirected from chronic granulocytic leukaemia)

chronic myeloid leukaemia

An indolent leukaemia, characterised by increased mature granulocytes in the peripheral circulation.

Clinical findings
Often asymptomatic; otherwise with splenomegaly, left sided pain, general malaise, joint pain, low-grade fever, pancytopaenia resulting in increased infections, anaemia, thrombocytopaenia.
 
Genetics
Philadelphia chromosome, a fusion gene bcl-abl from a 9:22 translocation, resulting in a gene product with tyrosine kinase activity.

Management
Imatinib mesylate induces major cytogenetic responses in 60% of patients with chronic-phase CML and complete haematologic responses in 95% of CML patients.

chronic myeloid leukaemia

A myeloproliferative disorder caused by a constitutively active BCR-ABL tyrosinase kinase. It has been found that continuous treatment of chronic phase chronic myeloid leukaemia with the drug imatinib can induce durable responses of five years or more in a high proportion of patients
References in periodicals archive ?
Chronic myeloid leukaemia is also known as chronic myelogenous leukaemia or chronic granulocytic leukaemia. White blood cells are affected when the bone marrow produces an unusual number of white blood cells.

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