linear IgA dermatosis

(redirected from chronic bullous dermatosis)

linear IgA dermatosis

An autoimmune, subepidermal vesiculobullous disease that may be idiopathic, drug-induced (especially by vancomycin) or triggered by a preceding infection or cancer. It is similar to bullous pemphigoid dermatitis herpetiformis, associated with HLA-B8 and gluten sensitivity and linear deposition of IgA along the basement membrane, and often has circulating IgA antibodies against part of the 180-kD bullous pemphigoid antigen BPAg2. Remission occurs in 64% of children within 2 years of onset (average age of child onset, 4 years) and 48% of adults within 5–6 years of onset (average age of adult onset, 52).

Clinical findings
Prolonged prodromal itching, transient pruritus or burning before lesions appear; ocular manifestations are characterised by pain, grittiness or discharge. Bullae may be chronic or appear acutely, as seen in drug-induced disease. Lesions in children are typically located over the lower abdomen and anogenital region; in adults, the lesions overlie the trunk and limbs.

Linear IgA deposition along the basement membrane by direct immunofluorescence.

Leave bullae intact; cover ruptured lesions and erosions with sterile dressings.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The sensitivity of DIF was 92.3% (12/13) in the pemphigus group, 75% (3/4) in bullous pemphigoid, 66.7% (2/3) in dermatitis herpetiformis, while it was 100% (3/3) each in linear IgA disease and chronic bullous dermatosis of childhood.
Bullous systemic lupus erythematosus (BSLE) is an autoimmune and chronic bullous dermatosis. It is characterized by distinctive clinical and histological features that can occur in the course of systemic lupus erythematosus (SLE) or its initial presentation.
Diseases such as scabies, chronic bullous dermatosis of childhood and verruca planar that were misdiagnosed by referring primary care doctors will help inform modification of dermatology educational curriculum.

Full browser ?