He trained in pediatrics, nephrology and transplantation immunology, and directs a research program focused on the understanding of chronic allograft rejection
with a goal to enhance long-term outcomes following solid organ transplantation.
CMV disease presents with clinical manifestations, as well as indirect effects including bacterial or fungal superinfections, acute or chronic allograft rejection
, and allograft loss .
Nevertheless, acute allograft dysfunction and acute and chronic allograft rejection
have remained unaffected .
Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection
. J Am Soc Nephrol.
These cells have been shown to promote induction of regulatory T cells that possess the potential to prevent acute and chronic allograft rejection
. Experimental findings from both research areas are discussed in support of the notion that presentation of alloantigens under subimmunogenic noninflammatory conditions, achieved by vigorous inhibition of oxidative injury-induced allograft inflammation (known to occur in both the deceased donor and the recipient during allograft reperfusion), may lead to the induction of tolerogenic dendritic cell-mediated regulatory T cells, thereby offering a realistic opportunity to induce allotolerance in transplant recipients.
It is noteworthy that VDR agonist beneficial effects have been shown in different models of experimental organ transplantation as well--heart [98, 108-110], kidney [111, 112], liver [113, 114], pancreatic islets [71, 115-117], skin , and small bowel allografts --since they delay acute and chronic allograft rejection. The latter effect, probably the most interesting in terms of potential clinical application, involves also the reduction of vascular intimal thickening--for example, due to vascular smooth muscle and endothelial cells hyperplasia--in association with a lesser extent of immune cell infiltration, after the treatment with VDR agonists .
Adorini, "Inhibition of acute and chronic allograft rejection in mouse models by BXL-628, a nonhypercalcemic vitamin D receptor agonist," Transplantation, vol.
(1,2) Acute tubular necrosis, acute and chronic allograft rejection
and immunosuppressive medications-induced nephropathy are among the medical complications.
Their topics include possible retrovirus vectors, adeno and adeno-associated virus vectors, gene therapy for acute renal failure due to ischemia-reperfusion issues and acute injuries, and treatment for chronically deteriorating renal function and renal fibrosis, and treatment for acute and chronic allograft rejection
. Articles include comprehensive references and the editors provide author and subject indices.
As depicted in Figure 3, results suggest a major contribution of ERK and MLC phosphorylation in a calcium independent manner and that the remodelling in EC structure may be involved in chronic allograft rejection
. Monocyte infiltration occurs during graft injury and may also contribute to the risk of TG.
This finding is consistent with a previous study that showed that proteinuria is associated with more severe acute and chronic allograft rejection
Macrophages are also able to infiltrate heart allografts and contribute to transplant vasculopathy in an animal model of chronic allograft rejection