chronic active hepatitis

Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.
Related to chronic active hepatitis: hepatitis, Chronic Persistent Hepatitis

chron·ic act·ive hep·a·ti·tis

hepatitis with chronic portal inflammation that extends into the parenchyma, with piecemeal necrosis and fibrosis that usually progresses to a coarsely nodular postnecrotic cirrhosis.

chronic active hepatitis (CAH)

a potentially fatal form of hepatitis complicated by portal inflammation and extending into the parenchyma. There may be progressive destruction of the liver lobule with necrosis and fibrosis leading to scarring and cirrhosis. Possible causes include viral infections, drugs, and autoimmune reactions.

chronic active hepatitis

1. Obsolete term. See Chronic hepatitis.
2. Chronic viral hepatitis.

chron·ic act·ive hep·a·ti·tis

(kronik aktiv hep-ă-tītis)
Liver disease with portal inflammation that extends into the parenchyma, and usually progresses to a coarsely nodular postnecrotic cirrhosis.


inflammation of the liver which may be toxic or infectious in origin; characterized by signs due to diffuse injury to the liver. See also liver dysfunction. There are a number of etiologically specific hepatitides which are listed under their individual headings. They are avian vibrionic hepatitis, infectious canine hepatitis (see below), infectious necrotic hepatitis, duck hepatitis, turkey hepatitis, inclusion body hepatitis, mouse hepatitis, postvaccinal hepatitis, toxemic jaundice, and those caused by fasciola and fascioloides, cysticercus, and plant toxins including pyrrolizidine alkaloids, sporidesmin, aflatoxin. See also hepatosis dietetica.

hepatitis A, B, C, D and E viruses
causes of hepatitis in humans and some nonhuman primates.
avian vibrionic hepatitis
a disease of domesticated poultry which has disappeared from those areas in the USA which were its sole habitat. Vibrio-like organisms were isolated from the outbreaks which occurred.
cholangiolitic hepatitis
chronic active hepatitis
a chronic inflammatory liver disease in humans, probably of several types with different causes, but with distinctive histopathological features of piecemeal necrosis, bridging fibrosis and active cirrhosis. A similar, but not identical disease of unknown etiology has been described in dogs.
copper-induced hepatitis
see bedlington terrier copper-associated hepatopathy.
duck hepatitis
see duck hepatitis.
gosling hepatitis
see goose hepatitis.
infectious canine hepatitis
an acute, highly contagious disease, occurring mainly in young dogs, caused by canine adenovirus type 1. Many dogs experience subclinical infections. Those with clinical signs show fever, depression, vomiting and abdominal pain. The course is short and in severe cases death occurs within a few days. Peracute infections occur in very young puppies. Mild infections may cause only vague signs of malaise and anorexia and many cases are not diagnosed. Dogs recovering from infection sometimes develop corneal edema ('blue eye'). A chronic hepatitis is reported as an occasional sequela. The disease can be prevented by vaccination.
mouse hepatitis
a coronavirus disease which causes heavy losses in baby mice. It is characterized by tremor, jaundice and hemoglobinuria.
mycotic hepatitis
commonly caused in cattle by extension from mycotic rumenitis due to lactic acid indigestion and damage to ruminal epithelium.
necrotic hepatitis
see infectious necrotic hepatitis.
porcine hepatitis E virus
an enteric virus of pigs related to human hepatitis E that is not known to be pathogenic.
toxipathic hepatitis
hepatitis caused by toxins, especially ingested plant toxins, e.g. some pyrrolizidine alkaloids, sporidesmin, aflatoxin.
trophopathic hepatitis
see trophopathic hepatitis.
turkey hepatitis
see turkey hepatitis.
hepatitis X
a hepatoxic disease of dogs and pigs caused by aflatoxins. See also mycotoxicosis.
References in periodicals archive ?
4] Nonstandard abbreviations: Ci, cirrhosis; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase; HCV, hepatitis C virus; CAH, chronic active hepatitis C; MNL, mononuclear leukocyte; PML, polymorphonuclear leukocyte; and RT-PCR, reverse transcription-PCR.
Chronic active hepatitis B (CAHB) is a persistent infection leading to inflammation of the liver.
About 5-10% of infected individuals become chronic carriers, and about 25% of chronic carriers in turn develop chronic active hepatitis.
The Phase 2 study indicated that oral administration of EHT899 to patients with HBV associated chronic active hepatitis resulted in a reduction in the viral load and liver inflammation, a decrease in liver enzymes circulating in the blood and/or an enhancement of anti-viral T-cell response.
HBV- associated chronic active hepatitis afflicts an estimated 350 million people worldwide.
Weiner commented on the status of other human clinical trials of Enzo's immune regulation therapy for individuals suffering from chronic active hepatitis associated with hepatitis C virus, hepatocellular cancer and Crohn's Disease.
Ribavirin capsules are currently being evaluated investigationally in the treatment of chronic active hepatitis C in three Phase III trials in the United States and Europe.
Ribavirin is not currently indicated for treatment of chronic active hepatitis C in the U.
and European Phase III clinical trials of Virazole against chronic active hepatitis C.
She is currently enrolling patients in a Phase I trial to investigate the use of activated cellular therapy with patients co-infected with HIV/AIDS and chronic active hepatitis B or C.
Proceeds will be used to complete Phase III clinical trials and related projects, evaluating the company's proprietary antiviral, Virazole, in the treatment of chronic active hepatitis C; to fund continued development of certain anticancer and immune-stimulatory compounds; to fund other research, such as the company's new antisense pharmaceutical discovery program; and for general working capital.
13, 1998--Neoprobe Corporation (NASDAQ/NMS:NEOP) today announced the initiation of patient enrollment in a Phase I trial to investigate the use of activated cellular therapy (ACT) with patients co-infected with HIV/AIDS and chronic active hepatitis B or C.

Full browser ?