peptic duodenitis

(redirected from chronic active duodenitis)

peptic duodenitis

A condition caused by chronic exposure to excess hydrochloric acid, which is characterised by inflammation, and most prominent in the duodenal bulb (D1), associated with Helicobacter pylori infection, chronic active gastritis and peptic ulcer disease. Peptic duodenitis is at the banal end of the spectrum of upper GI inflammation, at the other end of which is peptic ulcer disease.

Endoscopy
Erythema (blood is shunted to the tips of the villi), mucosal friability, regional nodularity (Brunner’s gland hyperplasia). There is often a poor correlation between endoscopy and histology; extreme cases are eroded and ulcerated.

DiffDx, duodenitis
Coeliac disease, Crohn’s disease, drug-induced inflammation, parasites, ulcerative colitis.
References in periodicals archive ?
(46) A total of 52% of cases had chronic active duodenitis characterized by villous blunting, lamina propria expansion by mononuclear cells, neutrophilic cryptitis, and crypt abscess formation; 16% of cases showed inflammation with apoptosis and resembled acute GVHD; and 5% of cases were indistinguishable from celiac disease, with extensive intraepithelial lymphocytosis.
Endoscopic gastric and duodenal biopsies showed chronic gastritis and partial villous atrophy, and chronic active duodenitis. A blood marrow aspiration biopsy revealed active normocellular bone marrow.
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