3), for which negative test results from a bacterial reverse gene mutation test, an in vitro mammalian cell gene mutation test, and an in vitro mammalian chromosome aberration
assay have been submitted by ECHA registrants (all with a Klimisch score of 1) (ECHA, 2017b).
such as sticky chromosomes, bridges, fragments, and binuclei were observed and recorded.
Determination of genotoxic effects of chlorfenvinphos and fenbuconazole in Allium cepa root cells by mitotic activity, chromosome aberration
, DNA content, and comet assay.
They found a strong correlation between the size of radiotherapy target field and the yield of radiation-induced chromosome aberrations
, indicating that late toxic effects of radiotherapy might be determined by such cytogenetic assessment.
Few studies of cancer incidence among veterans or peacekeepers serving in the Balkan area or local populations showed a significant increase of chromosome aberrations
and cancer cases compared to the control a subjects [13,14] which some attributed to exposure to depleted uranium.
Terzi, "Determination of genotoxic effects of copper sulphate and cobalt chloride in Allium cepa root cells by chromosome aberration
and comet assays," Chemosphere, vol.
in Plants as a Monitoring System.
(1) Their research showed that a battery of three in vitro genotoxity tests-Ames plus mouse lymphoma assay plus in vitro micronucleus or chromosome aberrations
test was able to discriminate rodent carcinogens and non-carcinogens.
d) the frequencies of cells with chromosome aberrations
among 100 metaphase (Souza, 2000).
An Allium cepa chromosome aberration
test that can serve as a rapid screen for toxic effects of chemicals is among them (Grant, 1994, Bolle et al.
Because of the potential environmental and human health impact connected with the heavy use of pesticides, the pesticides, dithane, malathion and garden ripcord were assessed for inhibition of cell division (cytoxicity) and genotoxicity using the Allium cepa chromosome aberration
assay, in which many environmental chemicals have not been evaluated.
Tests performed were acute oral toxicity, repeated dose 28-day oral toxicity, bacterial reverse mutation, in vitro chromosome aberration
, micronucleus and dermal sensitization, as well as a 4-week immunotoxicity study.