EDEM3(redirected from chromosome 1 open reading frame 22)
EDEM3A gene on chromosome 1q25 that encodes an enzyme which accelerates endoplasmic reticulum-associated degradation (ERAD), extracting misfolded—but not productively folded—glycoproteins from the calnexin cycle and targeting them for degradation by proteasomes. It is thought to have mannosidase activity.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.