WLS
(redirected from chromosome 1 open reading frame 139)WLS
A gene on chromosome 1p31.3 that encodes a G protein-coupled receptor which regulates the sorting and secretion of Wnt proteins by a feedback regulatory mechanism. WLS plays a key role in regulating expression, subcellular location, binding and organelle-specific association of Wnt proteins, and plays a key role in establishing anterior-posterior body axis formation during development.Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.