chromosomal breakage

chromosomal breakage

The disruption of a chromosome, as by radiation or toxic chemicals. When this occurs, the two fragments may rejoin, or a fragment may rejoin another broken chromosome. Unrepaired chromosome breaks are associated with many malignant and premalignant conditions.
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from chromosomal breakage or from chromosomal mal-segregation.
Blood and bone marrow Culture, Typhi dot, Dengue Ig M, Hepatitis serology (HBsAg, anti HCV antibodies), chromosomal breakage for Fanconi anemia and serum B 12 and RBC folate level were done in selected patients.
Hypocellular marrow was found in 13/26(50%) patients, out of them two had Fanconi anemia suggested by chromosomal breakage, two had enteric fever also suggested by positive typhi dot and nine patients had idiopathic aplastic anemia, their serology were also negative for hepatitis B and C.
This model allows analysis of pooled data over groups of individuals to establish non-random site-specific chromosomal breakage with respect to total breakage.
It detects micronuclei formed from chromatin that are displaced as result of chromosomal breakage.
New telomere formation after developmentally regulated chromosomal breakage during the process of chromatin diminution in Ascaris lumbricoides.
Effect of oxidants and antioxidants on chromosomal breakage in Fanconi anemia lymphocytes.
Courts have held that chromosomal breakage is sufficient to satisfy the present physical injury requirement.
The disease carries an increased risk of leukemia and lymphoma, and is one of a small group of inherited diseases in which an abnormal amount of unrepaired chromosomal breakage occurs.
93%) OSCC was found thus concluding that this could be due to chromosomal breakage associated with chromosomal translocation which may in turn lead to transposition and activation of oncogenes (40)
Similarly, this approach established the role of [Beta]-pol in long patch repair and established that the failure of this repair system can lead to chromosomal breakage and apoptosis (15,16).
Multicolour FISH detection if radioactive iodine induced 17ce-p53 chromosomal breakages in buccal cells from therapeutically exposed patients.