chromosomal breakage

chromosomal breakage

The disruption of a chromosome, as by radiation or toxic chemicals. When this occurs, the two fragments may rejoin, or a fragment may rejoin another broken chromosome. Unrepaired chromosome breaks are associated with many malignant and premalignant conditions.
References in periodicals archive ?
Mutations in the FANCA gene leads to chromosomal breakage and increased sensitivity to oxidative and environmental stress.
For the examination of chromosomal breakage, the preparations spread with solid staining method and dried were stained with 20% Giemsa (Merck, Darmstadt, Germany).
These cells are characterized by markers that signal unrepaired DSBs, like the presence of [gamma]H2AX, chromosomal breakage, [26, 29, 30] and micronuclei formation.
These depend on the origin of micronucleus itself i.e., from chromosomal breakage or from chromosomal mal-segregation.
Blood and bone marrow Culture, Typhi dot, Dengue Ig M, Hepatitis serology (HBsAg, anti HCV antibodies), chromosomal breakage for Fanconi anemia and serum B 12 and RBC folate level were done in selected patients.
This model allows analysis of pooled data over groups of individuals to establish non-random site-specific chromosomal breakage with respect to total breakage.
It detects micronuclei formed from chromatin that are displaced as result of chromosomal breakage. These nuclei are formed outside the main nucleus of the dividing cell.
New telomere formation after developmentally regulated chromosomal breakage during the process of chromatin diminution in Ascaris lumbricoides.
Effect of oxidants and antioxidants on chromosomal breakage in Fanconi anemia lymphocytes.
Courts have held that chromosomal breakage is sufficient to satisfy the present physical injury requirement.
The disease carries an increased risk of leukemia and lymphoma, and is one of a small group of inherited diseases in which an abnormal amount of unrepaired chromosomal breakage occurs.
Mutation in the FANC-A gene leads to chromosomal breakage and increased sensitivity to oxidative and environmental stress.