Curcumin (up to 500 and 160 [micro]g/plate) and curcumin oleoresin (up to 160 [micro]g/plate) have not shown mutagenicity in bacterial reverse mutation tests [27, 28], whereas curcumin induced chromosomal aberrations
without metabolic activation in CHO cells at 10 [micro]g/mL [29, 30].
A total of 214 congenital CNS anomalies, including 28 among the cases with chromosomal aberrations
(13%), were identified on prenatal ultrasonography and were studied (Supplemental Table 1; see supplemental digital content containing 8 tables at www.archivesofpathology.org in the February 2017 table of contents).
in bleomycin control were significantly high when compared with the negative control.
UV-B radiation caused chromosomal aberrations
and induced abnormal microtubule arrays, including an asymmetric PPB, asymmetric spindle, and defective phragmoplast.
Table 1: Summary of some landmark genotoxicity studies in fish using chromosomal aberration
test: a review.
Moreover, this treatment also induced highly significantly (Pless than 0.01) chromosomal aberrations
in the bone marrow cells 24 h after heptaplatin administration, but no significant change s were observed 48 or 72 h after heptaplatin administration (Table II).
test on higher doses were not performed as mitotic cells could not be retrieved from culture due to toxicity of pure Imidazole at high concentration.
CTAs = Chromatid-type aberrations, CSAs = Chromosome-type aberrations, CAs = Chromosomal aberrations
, SD = Standard deviation
After this the root tips were hydrolyzed in 1N HCL at 60[degrees]C for 10 minutes and stained with acetocarmine for 20 minutes and then squashed on glass slide under 45% acetic acid to determine the mitotic index and the presence of chromosomal aberrations
Nowadays, it is generally accepted that the high frequency of cytogenetic biomarkers, chromosomal aberrations
, can predict an increased risk of genotoxic effect in children after exposure to PAHs.
The most commonly assays used for studying mutagenicity of various pollutants in plants are based on the detection of chromosomal aberrations
in Allium cepa (Fiskesjo, 1995, Ma et al.
The frequency and types of chromosomal aberration
were determined by examining about 1000 dividing cells fro m 10 root tips per treatment.