chromophobe renal cell carcinoma

chromophobe renal cell carcinoma

a low-grade renal cell carcinoma composed of large polygonal cells with well-defined borders and amphophilic or pale cytoplasm. These cells grow in solid sheets, but focally they may form tubules, trabeculae, or cysts.

chromophobe renal cell carcinoma

An uncommon (4–5% of all renal tumours) renal cell carcinoma with relatively indolent growth and histologic changes of renal oncocytoma. It is thought to arise in the intercalated cells of the collecting ducts.

DiffDx
Oncocytoma, renal cell carcinoma—granular cell type.
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E, Chromophobe renal cell carcinoma can rarely have focally papillary component with typical chromophobe renal cell carcinoma cell morphology.
Among them, renal oncocytoma and chromophobe renal cell carcinoma (RCC) originate from intercalated cells in the collecting duct and share some morphologic, histologic, electron microscopy findings, and immunohistochemical characteristics (2, 3).
MicroRNA expression profiles predict clinical phenotypes and prognosis in chromophobe renal cell carcinoma. Sci Rep 2015;5:10328.
Unfortunately, most oncocytomas are difficult to differentiate from chromophobe renal cell carcinoma due to overlapping ultrastructural, immunohistochemical, and morphological characteristics [5].
However, the differentiation between the benign oncocytoma [3] and its malignant counterpart, the chromophobe renal cell carcinoma, is a continuous challenge for all diagnostic disciplines, such as radiology, urology, and pathology, since there are no absolute distinctive diagnostic criteria.
Nagashima, "Chromophobe renal cell carcinoma. Clinical, pathological and molecular biological features," Pathol Int, vol.
(3) Often times it is difficult to histologically distinguish clear-cell renal cell carcinoma from chromophobe renal cell carcinoma and having the difference in the levels of CB1 receptor, i.e., down-regulated in clear-cell renal cell carcinoma while maintaining normal levels in chromophobe, could serve as an important diagnostic tool to differentiate between the two.
Abdelsalam et al., "Chromophobe renal cell carcinoma occurring in the renal allograft of a transplant recipient presenting with weight loss," Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol.
Li, "Metachronous contralateral testicular and bilateral adrenal metastasis of chromophobe renal cell carcinoma: a case report and review of the literature," Journal of Zhejiang University Science B: Biomedicine & Biotechnology, vol.
Colloidal iron staining in renal epithelial neoplasms, including chromophobe renal cell carcinoma: emphasis on technique and patterns of staining.
Chromophobe renal cell carcinoma (ChRCC) is a variant of parenchymal renal cell carcinoma, comprising 2-5% of all renal cell carcinoma and characterised by unique morphological, histochemical, ultrastructural and genetic features (1-5).