chromophobe renal cell carcinoma

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chromophobe renal cell carcinoma

a low-grade renal cell carcinoma composed of large polygonal cells with well-defined borders and amphophilic or pale cytoplasm. These cells grow in solid sheets, but focally they may form tubules, trabeculae, or cysts.

chromophobe renal cell carcinoma

An uncommon (4–5% of all renal tumours) renal cell carcinoma with relatively indolent growth and histologic changes of renal oncocytoma. It is thought to arise in the intercalated cells of the collecting ducts.

DiffDx
Oncocytoma, renal cell carcinoma—granular cell type.
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References in periodicals archive ?
It has been proposed that multiple chromosomal losses, including that of chromosome 21, may result in progression of oncocytoma to chromophobe carcinoma.
High incidence of chromosome 1 abnormalities in a series of 27 renal oncocytomas: cytogenetic and fluorescence in situ hybridization studies
Observation of these unusual tumors is important because it suggests a spectrum between oncocytoma and chromophobe carcinoma.
Bilateral Renal Oncocytosis With Renal Failure
Mostly sarcomatoid carcinomas are found in association with conventional (clear cell) renal carcinoma, but there are occasional descriptions of sarcomatoid transformation of chromophobe carcinoma,[8,9] collecting duct carcinoma,[10] and papillary carcinoma.
Sarcomatoid Renal Cell Carcinoma of Papillary Origin: A Case Report and Cytogenetic Evaluation

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