chromophobe renal cell carcinoma

(redirected from chromophobe RCC)

chromophobe renal cell carcinoma

a low-grade renal cell carcinoma composed of large polygonal cells with well-defined borders and amphophilic or pale cytoplasm. These cells grow in solid sheets, but focally they may form tubules, trabeculae, or cysts.

chromophobe renal cell carcinoma

An uncommon (4–5% of all renal tumours) renal cell carcinoma with relatively indolent growth and histologic changes of renal oncocytoma. It is thought to arise in the intercalated cells of the collecting ducts.

DiffDx
Oncocytoma, renal cell carcinoma—granular cell type.
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Low-grade oncocytic renal neoplasms include oncocytoma, eosinophilic variant of chromophobe RCC, or hybrid oncocytic tumors associated with Birt-Hogg-Dube syndrome and oncocytic papillary RCCs.
According to Hes O, Michal M the presence of GHG in a renal tumour may be of aid for excluding a diagnosis of chromophobe RCC or oncocytoma.
In this study, we investigated the MRI features of renal tumors, namely T2 signal intensities, T2 signal intensity ratios, enhancement patterns, and enhancement ratios that might allow differentiation of oncocytoma from chromophobe RCC.
Papillary RCC was found in 3 of the male and 2 of the female patients and chromophobe RCC was detected in 1 of the males and 2 of the females.
All other groups contained 20 tumor samples (clear cell RCC, eosinophilic/oncocytic variant of clear cell RCC, chromophobe RCC, eosinophilic/oncocytic variant of chromophobe RCC, and oncocytoma) according to the AJCC 2010/UICC 2009 classification.
In addition, a previous report indicated that CD10 positivity is useful for pathological diagnosis of clear cell or papillary RCC, and we could eliminate the chromophobe RCC [31].
Herein, we describe a rare case of incidental de novo eosinophilic variant of chromophobe RCC (ChRCC) in a renal allograft 11 years after transplantation, discuss the histopathological differential diagnosis, and comment on cancer screening in renal transplant recipients.
It is classified into clear cell RCC accounting for (75%) of cases, papillary RCC (10-15%), chromophobe RCC (5%), collecting duct RCC (<1%), and unclassified subtype [2].
Others have reported that patients with either papillary RCC or chromophobe RCC are more likely to have secondary colon cancer compared to patients with clear cell RCC; however, the literature lacks information regarding the histological subtype of RCC and synchronous gastrointestinal tumors [15].
Chromophobe RCC (CH- RCC) is the third most common subtype, comprising approximately 5% of all RCCs.2
The Rosetta Kidney Cancer Test accurately classifies the four most common kidney tumors: clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe RCC and oncocytoma.
As seen in our patient the occurrence of multifocality has been found greater in patients with papillary RCC than among patients with clear cell or chromophobe RCC and these patients are more likely to experience a contralateral kidney recurrence8.