Low-grade oncocytic renal neoplasms include oncocytoma, eosinophilic variant of
chromophobe RCC, or hybrid oncocytic tumors associated with Birt-Hogg-Dube syndrome and oncocytic papillary RCCs.
According to Hes O, Michal M the presence of GHG in a renal tumour may be of aid for excluding a diagnosis of
chromophobe RCC or oncocytoma.
In this study, we investigated the MRI features of renal tumors, namely T2 signal intensities, T2 signal intensity ratios, enhancement patterns, and enhancement ratios that might allow differentiation of oncocytoma from
chromophobe RCC.
Papillary RCC was found in 3 of the male and 2 of the female patients and
chromophobe RCC was detected in 1 of the males and 2 of the females.
All other groups contained 20 tumor samples (clear cell RCC, eosinophilic/oncocytic variant of clear cell RCC,
chromophobe RCC, eosinophilic/oncocytic variant of
chromophobe RCC, and oncocytoma) according to the AJCC 2010/UICC 2009 classification.
In addition, a previous report indicated that CD10 positivity is useful for pathological diagnosis of clear cell or papillary RCC, and we could eliminate the
chromophobe RCC [31].
Herein, we describe a rare case of incidental de novo eosinophilic variant of
chromophobe RCC (ChRCC) in a renal allograft 11 years after transplantation, discuss the histopathological differential diagnosis, and comment on cancer screening in renal transplant recipients.
It is classified into clear cell RCC accounting for (75%) of cases, papillary RCC (10-15%),
chromophobe RCC (5%), collecting duct RCC (<1%), and unclassified subtype [2].
Others have reported that patients with either papillary RCC or
chromophobe RCC are more likely to have secondary colon cancer compared to patients with clear cell RCC; however, the literature lacks information regarding the histological subtype of RCC and synchronous gastrointestinal tumors [15].
Chromophobe RCC (CH- RCC) is the third most common subtype, comprising approximately 5% of all RCCs.2
The Rosetta Kidney Cancer Test accurately classifies the four most common kidney tumors: clear cell renal cell carcinoma (RCC), papillary RCC,
chromophobe RCC and oncocytoma.
As seen in our patient the occurrence of multifocality has been found greater in patients with papillary RCC than among patients with clear cell or
chromophobe RCC and these patients are more likely to experience a contralateral kidney recurrence8.
