papillary renal cell carcinoma

papillary renal cell carcinoma

the second most common form of renal cell carcinoma, accounting for approximately 15% of all renal malignancies; histologically similar to papillary carcinomas in other organs. Histogenetically and genetically, it is distinct from clear cell renal carcinoma. It is found in 80% of people who have a tuberous sclerosis.

Synonym(s): chromophil renal cell carcinoma

PRCC

A gene on chromosome 1q21.1 that encodes a protein thought to play a role in pre-mRNA splicing.

Molecular pathology
PRCC translocation (X;1)(p11;q21) to TFE3 is associated with papillary renal cell carcinoma.