papillary renal cell carcinoma

(redirected from chromophil renal cell carcinoma)

papillary renal cell carcinoma

the second most common form of renal cell carcinoma, accounting for approximately 15% of all renal malignancies; histologically similar to papillary carcinomas in other organs. Histogenetically and genetically, it is distinct from clear cell renal carcinoma. It is found in 80% of people who have a tuberous sclerosis.
Synonym(s): chromophil renal cell carcinoma

PRCC

A gene on chromosome 1q21.1 that encodes a protein thought to play a role in pre-mRNA splicing.

Molecular pathology
PRCC translocation (X;1)(p11;q21) to TFE3 is associated with papillary renal cell carcinoma.
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Typical chromophobe and chromophil renal cell carcinomas also contain such vesicles, but to a much lesser extent.[17] The high lipid content in this particular type of tumor may be related to the formation of the myospherules.
Myospherulosis in Renal Cell Carcinoma

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