chromogranin A


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chromogranin A

A major protein in catecholamine storage vesicles (chromaffin granules) of the adrenal medulla, which is co-released therefrom with catecholamines by exocytosis.
 
Abnormal expression
Increased in anterior pituitary adenoma, parathyroid carcinoma, medullary thyroid carcinoma, carcinoid tumour, pancreatic islet cell tumour, small cell lung carcinoma.

Ref range
10–50 ng/mL.
References in periodicals archive ?
Chromogranin A is a 439-residue-long glycoprotein [15,16], a member of a larger family of soluble secretory proteins (granin proteins) that includes also chromogranin B (CgB), secretogranin (Sg) II (CgC), Sg III (1B1075), Sg IV (HISL-19), Sg V (7B2) and Sg VI (NESP55), Sg VII (VGF), and Sg VIII (proSAAS) [12], localized in secretory granules of neuroendocrine cells, neurons, and the adrenal medulla [17].
The authors want to thank Novartis Pharma AG for their support in providing Chromogranin A assay kits throughout the study.
Diagnosis can be made by the clinical picture and supported by imaging, endoscopy, or tumor markers such as chromogranin A and serotonin.
Using the range established by the EDI Chromogranin A ELISA Kit, the patients were divided into three groups based on baseline CgA levels: normal CgA (<120 ug/ml), under 3 time normal (360 ug/ml).
Carcinoid tumours secrete a variety of tumour markers, including 5HIAA, Chromogranin A, cytokeratins, CD56 and Ki67.
7 August 2014 - A study, carried out by Chinese researchers and published today in BMC Endocrine Disorders, has demonstrated that Chromogranin A (CgA) is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumours (PNETs) but not for insulinomas.
Immunohistochemical studies were positive for synaptophysin and CD56 (NCAM), chromogranin A, epithelial antigen, and CAM 5.2/AE-1.
The cases were stained for TTF-1, EMA, low-molecular-weight cytokeratin (CAM 5.2), endothelial cell marker (CD31), surfactant protein B (PE10), and chromogranin A. Immunohistochemical studies were performed on formalin-fixed, paraffin-embedded tissue sections.
The tests recommended by the report include DOTA-Octreotide scan, Upper and Lower GI endoscopies with biopsies (if required), repeat Chromogranin A and B levels for comparison, serum catecholamine/meanphrine levels, 24 hours urinary VMA and Catecholamnine levels and MR scan for spine.
Products to note from this catalog include Euro Diagnostica's gold standard anti-CCP ELISA, ANCA ELISA, Pertusscan ELISA, Complement, as well as endocrine and tumor markers including Chromogranin A and B assays.
Human chromogranin A (CgA), a member of the granin family, is an acidic 439-amino acid protein with a widespread expression in endocrine cells and neurons (1-3).