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A soluble and secretory hormone proteins of chromaffin granules. Chromogranins A, an acidic glycoprotein, comprises about 50% of the total protein of the granule matrix. Other types are chromogranin 13 and secretogranin II.
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References in periodicals archive ?
CT-angiography, advanced hemodynamic monitoring, and determination of catecholamines, chromogranin A in plasma, and 5-hydroxyindoleacetic acid (5-HIAA) in urine were performed.
Estimated chromogranin A concentration was in the normal range (36, 3ng/ml).
Additionally, plasma chromogranin A was markedly raised (16-fold) at time of consultation and prior to surgery (15-fold).
[6] One case of NK/T-cell lymphoma nasal type was diagnosed which showed reactivity for LCA, CD3, vimentin and non-reactive for CD5, EMA, NSE and chromogranin. However further IHC study for CD56 and granzyme B was advised for confirmation.
Immunohistochemically, the tumour cells were negative for PSA and positive for chromogranins (Fig.
Without a clinical history the diagnosis of these tumors can be very challenging, yet an immunohistochemistry panel consisting of melan-A, alpha inhibin, D11, calretinin, NSE, synaptophysin and chromogranin can be helpful in establishing the diagnosis.
CD 117, DOG 1, S100, CD34, desmin, and neuroendocrine markers such as chromogranin, synaptophysin, neuron-specific enolase, CD56, CD57, and PGP 9.5 are negative (1, 5).
Low Power View of H and E Carcinoid Tumour with Chromogranin (IHC) Positive Stain
With immunohistochemical staining the tumour cells showed strong diffuse positivity for neuron-specific enolase (NSE), chromogranin, and synaptophysin (Figure 5, 6, 7) and were negative for cytokeratin, TTF-1 & LCA.
One of the elements of glucagonoma diagnosis is histopathological examination including immunohistochemical staining such as chromogranin or synaptophysin specific for neuroendocrine tumors.