chromatolysis


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chromatolysis

 [kro″mah-tol´ĭ-sis]
1. the solution and disintegration of the chromatin of cell nuclei.
2. disintegration of the Nissl bodies of a neuron as a result of injury, fatigue, or exhaustion.

chro·ma·tol·y·sis

(krō'mă-tol'i-sis),
The disintegration of the granules of chromophil substance (Nissl bodies) in a nerve cell body that may occur after exhaustion of the cell or damage to its peripheral process; other changes considered part of chromatolysis include swelling of the perikaryon and shifting of the nucleus from its central position to the periphery.
[chromato- + G. lysis, dissolution]

chromatolysis

/chro·ma·tol·y·sis/ (kro″mah-tol´ĭ-sis) disintegration of Nissl bodies of a neuron as a result of injury, fatigue, or exhaustion.

chromatolysis

(krō′mə-tŏl′ĭ-sĭs)
n.
The dissolution or disintegration of chromophil material, such as chromatin, within a cell.

chro·mat′o·lyt′ic (-măt′l-ĭt′ĭk) adj.

chro·ma·tol·y·sis

(krō'mă-tol'i-sis)
The disintegration of the granules of chromophil substance (Nissl bodies) in a nerve cell body that may occur after exhaustion of the cell or damage to its peripheral process.
Synonym(s): chromolysis.
[chromato- + G. lysis, dissolution]

chromatolysis

Loss of the ability of a part of a cell to take up a stain from microscopic purposes. Nuclear chromatolysis implies dissolution of the nucleus.

chromatolysis

nerve cell Nissl bodies degradation following peripheral nerve fibre damage

chromatolysis

1. the solution and disintegration of the chromatin of cell nuclei.
2. disintegration of the Nissl bodies of a neuron as a result of injury, fatigue or exhaustion.
References in periodicals archive ?
Phosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve.
2] of a section square and by calculating the percentage of neurons with focal and total chromatolysis over the same area per 500 neurons of study layer in 5 brain sections from each animal.
In the cytoplasm of most remaining neurons, chromatolysis of various degrees developed ranging from reversible to irreversible with the presence of "shadow cells".
Caption: Figure 5: Histological changes in the cerebral cortex of the newborns at postnatal day 30 showing pyramidal neurons (PYC), degenerated pyramidal cells (PKC), and neurocyte chromatolysis (NCH).
Caption: Figure 7: Histological changes in the medulla oblongata of the newborns at postnatal day 30 showing medulla neurons (MeN), degenerated medullary cells (PKC), and neurocyte chromatolysis (NCH).
Both occipital cortices showed markedly diminished thickness, diffuse microspongiosis of the neuropil, neuronal chromatolysis, and neuronal death.
Chromatolysis and pycnotic changes, as well as a decrease (and sometimes a complete absence) of neuroendocrine granules, were dominated.
In particular, we observed focuses of tissue rarefaction and dystrophic changes in neurons in the form of chromatolysis and pycnotic changes in cortex, hypothalamus, and the cerebellum.
Histopathologic studies showed moderate neuronal degeneration characterized by neuronal hyperchromatosis, chromatolysis, and satellitosis (Figure 2, panel A).
Within the first few hours to days, morphologic changes occur in the cell body with the advent of chromatolysis.
Beginning on day 5, however, neuronal degeneration was seen in many areas, manifested by shrinkage of the perikaryon with intense eosinophilia of the cytoplasm, central chromatolysis, and condensation of the nucleus.
Vestibulocochlear Wallerian-like degeneration and retinal ganglion cell chromatolysis were also seen in dogs treated for 14 weeks at 180 mg/kg/day, a dose which resulted in a mean plasma drug level (Cmax) similar to that seen with the 60 mg/kg/day dose.