chromatolysis


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chromatolysis

 [kro″mah-tol´ĭ-sis]
1. the solution and disintegration of the chromatin of cell nuclei.
2. disintegration of the Nissl bodies of a neuron as a result of injury, fatigue, or exhaustion.

chro·ma·tol·y·sis

(krō'mă-tol'i-sis),
The disintegration of the granules of chromophil substance (Nissl bodies) in a nerve cell body that may occur after exhaustion of the cell or damage to its peripheral process; other changes considered part of chromatolysis include swelling of the perikaryon and shifting of the nucleus from its central position to the periphery.
[chromato- + G. lysis, dissolution]

chromatolysis

(krō′mə-tŏl′ĭ-sĭs)
n.
The dissolution or disintegration of chromophil material, such as chromatin, within a cell.

chro·mat′o·lyt′ic (-măt′l-ĭt′ĭk) adj.

chro·ma·tol·y·sis

(krō'mă-tol'i-sis)
The disintegration of the granules of chromophil substance (Nissl bodies) in a nerve cell body that may occur after exhaustion of the cell or damage to its peripheral process.
Synonym(s): chromolysis.
[chromato- + G. lysis, dissolution]

chromatolysis

Loss of the ability of a part of a cell to take up a stain from microscopic purposes. Nuclear chromatolysis implies dissolution of the nucleus.
References in periodicals archive ?
In histopathological examination, moderate-to-severe disruption in cellular arrangement of organ of corti, chromatolysis and reduction in spiral ganglion cells, irregular satellite cells, and vacuolization in stria vascularis were observed in the group given mercurochrome.
The group treated with moringa given at 250 mg/kg showed the same microscopic findings with that of the control; however, those administered with 500 mg/kg and 750 mg/kg showed the presence of reduction of hippocampal neurons, distortion and degenerative changes in neurons, and mild chromatolysis.
Phosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve.
In the present study, nicotine induced a delay in cell migration from the external granular layer to the internal layer and altered shape and pyknosis in Purkinje cells in the cerebellum and chromatolysis of neurons in the medulla oblongata, an effect that was markedly prevented in the C.
The percentage of neurons with focal and total chromatolysis decreased by 27% and 43%, respectively.
Both occipital cortices showed markedly diminished thickness, diffuse microspongiosis of the neuropil, neuronal chromatolysis, and neuronal death.
We also observed dystrophic changes in the neurons, including mainly chromatolysis in medial cortex and pycnotic changes in the upper layers.
Every 5th section was stained with thionine and studied light microscopically to identify neuronal somata with "typical chromatolysis" [3] or "cell body response" [4] and to compare the experimental (right) side with control (left) side.
From cytological point of view, GC pyknosis, chromatolysis, dissociation and their floating in antrum are essential to describe a real atresia (33, 37).
Occasional Purkinje neurons had nuclear chromatolysis. Unfortunately, brain and other tissues of the aborted foal were not formalin fixed.
In a postmortem study of nine patients with RA and myelopathy, Henderson and coworkers (31) noted that the cord pathology occurred mostly in the dorsal white matter of the spinal cord and was characterized by axonal degeneration, central chromatolysis, and axonal retraction.
In the central nervous system, the neural cell body undergoes chromatolysis with peripheral shifting of the Nissl bodies (stocked metabolites) and a decrease in their number.