chromatin assembly factor-1
chromatin assembly factor-1A protein encoded by CHAF1A on chromosome 19p13.3 that is critical for maintaining chromatin stability during DNA replication and repair.
CAF-1 is overexpressed in solid tumours—e.g., endometrium, uterine cervix, breast and renal. In most, CAF-1 overexpression is associated with a higher histologic grade and clinical stage, and is regarded as a predictor of adverse outcomes.
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