Evidence that MgATP primes adrenal chromaffin cells
to undergo exocytosis.
The downstream events following the tyrosine phosphorylation of the trk receptors are believed to be very similar, which also suggests the equivalence of the chromaffin cell
plasticity and neuronal plasticity.
Analgesia induced by isolated bovine chromaffin cells
implanted in rat spinal cord.
Because more than 90% of plasma metanephrine and about 27% of circulating normetanephrine are produced from their catecholamine precursors within chromaffin cells
and independently of exocytotic catecholamine release (Fig.
Finally, in medullar region, large chromaffin cells
and numerous blood vessels, similar to that described in Cavia porcellus were found (Kmiec and Kaczmarczyk, 2004).
However, sympathetic paraganglioma are usually secretory neuroendocrine tumors derived from chromaffin cells
Pheochromocytomas arise from the chromaffin cells
of the adrenal gland.
Approximately 85% arise from chromaffin cells
in the adrenal medulla, and 15% arise from chromaffin tissue in extra-adrenal sites extending from the neck to the pelvis, although most are found intra-abdominally.
Cg A, isolated from chromaffin cells
of the adrenal medulla, is an acidic glycoprotein with 439 amino acids (21) and is present in secretory dense core granules located within the cytoplasm of these NE cells (22), However, CgA production seems to depend on tumor type or tumor differentiation and the sensitivity of CgA detection in tissue or plasma may be low in moderately or poorly differentiated NE carcinomas (23).
In the second stage, beginning 48 hours after the injury, the adrenals are greatly enlarged but regain their lipoid granules, while the medullary chromaffin cells
show vacuolization; the edema begins to disappear, numerous basophiles appear in the pituitary; the thyroid shows a tendency towards hyperplasia (more marked in the guinea pig); general body growth ceases, and the gonads become atrophic; in lactating animals, milk secretion stops.
To evaluate the cytotoxic effect in cultured chromaffin cells
, LDH release assay has been used by (Sicard et al.
A primary response is the activation of brain centers, which eventually results in the release of cortisol from the steroid-producing cells and of catecholamines from the head kidney chromaffin cells