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These cell stain yellow brown with the chrome salts and hence are called chromaffin cells.
Rapid sprouting of filopodia in nerve terminals of chromaffin cells, PC12 cells, and dorsal root neurons induced by electrical stimulation.
The PCI 2 cell line is derived from an induced pheochromocytoma and, when grown in a serum-supplemented medium, PCI 2 cells exhibit many features of their normal counterparts, adrenal chromaffin cells (Greene and Tischler 1976).
Pheochromocytomas arise from the chromaffin cells of the adrenal gland.
Approximately 85% arise from chromaffin cells in the adrenal medulla, and 15% arise from chromaffin tissue in extra-adrenal sites extending from the neck to the pelvis, although most are found intra-abdominally.
Cg A, isolated from chromaffin cells of the adrenal medulla, is an acidic glycoprotein with 439 amino acids (21) and is present in secretory dense core granules located within the cytoplasm of these NE cells (22), However, CgA production seems to depend on tumor type or tumor differentiation and the sensitivity of CgA detection in tissue or plasma may be low in moderately or poorly differentiated NE carcinomas (23).
In the second stage, beginning 48 hours after the injury, the adrenals are greatly enlarged but regain their lipoid granules, while the medullary chromaffin cells show vacuolization; the edema begins to disappear, numerous basophiles appear in the pituitary; the thyroid shows a tendency towards hyperplasia (more marked in the guinea pig); general body growth ceases, and the gonads become atrophic; in lactating animals, milk secretion stops.
A primary response is the activation of brain centers, which eventually results in the release of cortisol from the steroid-producing cells and of catecholamines from the head kidney chromaffin cells.
Phaeochromocytoma is a catecholamine-secreting, neuroendocrine tumour arising from chromaffin cells.
The hypothesis is that bovine adrenal chromaffin cells express multiple subtypes that can be identified using receptor protection assays.