These cell stain yellow brown with the chrome salts and hence are called chromaffin
There is evidence to suggest that the plasticity of chromaffin
cells declines during development, which may overlap or be the same as early stages of ageing |17, 18~.
In this syndrome, patients develop polycythemia at a later age relative to HIF2A mutation carriers, but they appear to have a similar high risk of recurrent chromaffin
cell tumors, especially PGL [17, 53].
Grohovaz, "Mechanism of [Ca2+]i oscillations in rat chromaffin
Alvaro et al., "Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin
cells by interleukin-1beta: role of neuropeptide Y and nitric oxide," Journal of Neurochemistry, vol.
Tuominen, "Cotinine and nicotine inhibit each other's calcium responses in bovine chromaffin
cells," Toxicology and Applied Pharmacology, vol.
The columnar or polyhedral chromaffin
cells of the adrenal medulla of the African giant rat which form clusters and anastomosing cords separated by sinusoids had also been reported in mammals (Bacha & Bacha).
Mediastinal paragangliomas are extra adrenal chromaffin
cell tumours that account for fewer than 10% of all mediastinal neuroendocrine tumours.2 They represent only 2% of all catecholamine secreting tumours of the body and 0.3% of all mediastinal tumours.2 Paragangliomas maybe functional, if they synthesize and secrete catecholamines or non functional, if they synthesize but donot secrete catecholamines.3
Hu, "High-intensity training induces EIB in rats through neuron transdifferentiation of adrenal medulla chromaffin
cells," American Journal of Physiology--Lung Cellular and Molecular Physiology, vol.
Pheochromocytomas and paragangliomas (PPGLs)  are neuroendocrine tumors arising from adrenal and extraadrenal chromaffin
cells, respectively (1).
Catecholamine-producing tumors are neuroendocrine tumors that affect the chromaffin
cells of adrenal medulla and postganglionic fibers of the sympathetic nervous system.
A phaeochromocytoma is a rare neuro-endocrine tumour of the paraganglionic chromaffin
cells affecting 2-8 persons per million per year.[1-6] Although usually benign, around 10% are found to be malignant.[1,2,7] They can arise in the adrenal medulla and also, in around 10% of cases, in the extra-adrenal paraganglionic cells.[1,3-5] These extra-adrenal tumours are known as paragangliomas.