The circulation parameters usually used are the time of choroidal flush, the arm-to-retina circulation time, and the retinal circulation time (RT) .
We calculated the following phases in the transit of fluorescein in the fundus: (1) the time of the choroidal flush (sec), (2) the arm-to-retina time (sec), which reflects the early arteriolar phase and was recorded for the appearance of the retinal arterial fluorescence, and (3) the early and late phases of the retinal circulation time (RT: sec).
Table 2 summarizes the circulation time results (i.e., time of choroidal flush, arm-to-retina time, and early and late phases of RT), the retinal arteriosclerosis (Scheie classification), and the MBRs in the ONH obtained by LSFG.
Time of choroidal flush (r = 0.26, p = 0.005), arm-to-retina time (r = 0.28, p = 0.003), and the late phase of RT (r = 0.32, p = 0.0004) were significantly positively correlated with the progression of Scheie classification.
The choroidal flush and arm-to-retina times were significantly negatively correlated with MBR-V (r = -0.37, p <0.0001; r = -0.37, p <0.0001) and MBR-A (r = -0.27, p = 0.003; r = -0.25, p = 0.006), respectively.
Gender (men = 1, women = 0) was correlated significantly with the early phase (r = 0.19, p = 0.04) and late phase (r = 0.21, p = 0.02) of RT and tended to be correlated with the choroidal flush (r = 0.17, p = 0.07) and arm-to-retina times (r = 0.15, p = 0.10) but the correlation did not reach significance.
Table 7 shows the results of the multiple regression analysis for factors independently contributing to the time of the choroidal flush and the arm-to-retina time.
Our single regression analysis showed that the Scheie classification was significantly positively correlated with the time of choroidal flush, the arm-to-retina time, and the late phase of RT.
The results of the single regression analysis also revealed that the choroidal flush and arm-to-retina times were significantly negatively correlated with the MBR-V and MBR-A and that each phase of the RT was significantly negatively correlated with all sections of the MBR.
Our multiple regression analysis showed that the MBR-V and retinal arteriosclerosis by Scheie classification were significantly associated with the choroidal flush and arm-to-retina times.