This open-label, multicenter trial is designed to investigate single and multiple ascending doses of light-activated AU-011 in approximately 52 adult subjects with clinically diagnosed primary
choroidal melanoma.
(11) reported that patients who underwent cataract surgery had a 3.4-fold higher risk of developing
choroidal neovascularization.
We believe that the most likely reason was the air embolism via
choroidal vein.
The EDI mode of SD-OCT (Heidelberg Spectralis OCT; Heidelberg Engineering, Heidelberg, Germany) was used for obtaining the
choroidal measurements.
The enhanced depth imaging (EDI-optical coherence tomography) mode of Cirrus HD[TM] was used for subfoveal
choroidal thickness evaluation between retinal pigment epithelium and the internal scleral border from the thinnest zone corresponding fovea.
Choroidal thickness was measured manually using OCT (Heidelberg Spectralis, Heidelberg Engineering, Heidelberg, Germany) in increased imaging depth mode in order to optimize
choroidal resolution.
The most common ocular lesions were
choroidal tubercles (75%).
Hiroaki Endo, from Teine Keijinkai Hospital in Sapporo, Japan, and colleagues examined the
choroidal layer thickness in 268 eyes of 134 patients with diabetes mellitus and 72 healthy controls (92 eyes) to compare the findings based on medical history of systemic diabetes mellitus treatments and stage of diabetic retinopathy (DR).
The objective of this study is to look for presence of any Histopathological risk factors like, iris invasion,
choroidal invasion, trans-scleral migration and optic nerve involvement etc.
For more than 50 years, fluorescein angiography has been considered a gold standard for visualizing
choroidal neovascularization (CNV); however, this method has many drawbacks such as high camera cost, time-consuming process, and rarely, life-threatening allergic reactions [1].
Far less attention has been paid to
choroidal vasculopathy, despite clinical and experimental findings implicating
choroidal blood flow in the pathogenesis of diabetic retinopathy [7-9].
Presumed ocular histoplasmosis syndrome (POHS) can lead to central vision loss with development of
choroidal neovascularization (CNV).