chordoma


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chordoma

 [kor-do´mah]
a malignant tumor arising in the axial skeleton from embryonic remains of the notochord.

chor·do·ma

(kōr-dō'mă), [MIM*215400]
A rare neoplasm of skeletal tissue in adults, derived from persistent portions of the notochord; composed of cells arranged in lobules, with abundant myxoid stroma; some cells contain vacuoles that resemble soap bubbles (physaliphorous cells); most frequently in the region of the clivus or lumbar-sacral cord.
[(noto)chord + G. -oma, tumor]

chordoma

/chor·do·ma/ (kor-do´mah) a malignant tumor arising from the embryonic remains of the notochord.

chordoma

[kôrdō′mə] pl. chordomas, chordomata,
a rare tumor that develops from the fetal notochord. It is usually located in the midline, behind the sella; it is slow growing but highly invasive.

chordoma

An encapsulated, locally invasive malignant tumour that arises from the foetal notochord in the sacrococcygeal and sphenooccipital regions.
 
Epidemiology
Predominantly in older (age 50–70) men for sacrococcygeal region and age 20–40 for sphenooccipital chordoma.
 
Management
Surgery, RT.
 
Prognosis
Recurrence is common, often years after adequate therapy.

chor·do·ma

(kōr-dō'mă)
A rare neoplasm of skeletal tissue in adults, derived from persistent portions of the notochord.
[(noto)chord + G. -oma, tumor]

chordoma

A slow-growing tumour of the spine arising from remnants of the primitive NOTOCHORD. Chordomas rarely spread remotely, but can cause severe local damage.

chordoma

a malignant tumor arising from embryonic remains of the notochord.
References in periodicals archive ?
The three histological subtypes of chordoma are conventional (sometimes called classic) chondroid, and dedifferentiated.
They suggested a clinical trial of the PI3K inhibitors for this particular group of chordoma patients, who could benefit from existing treatments.
B]rachyury was identified as a sensitive and specific marker for chordoma with the ability to discern between extra-axial chordoma and other chordoma-like lesions such as parachordoma/myoepithelioma," explained Dr.
Primary chordoma of the nasal cavity: a rare site of presentation.
Thought to arise from cellular remnants of the notochord (the mesodermal precursor of the vertebral column), chordoma is a rare, slow-growing, locally-invasive malignant tumour.
On postoperative day 2, CC underwent a midline mandibulotomy-glossotomy approach for resection of a C1, C2, and C3 chordoma.
While chordomas represent a one-in-a-million diagnosis (300 Americans are diagnosed with chordomas each year), ProCure New Jersey has successfully treated six chordoma patients in just the past few months.
The most commonly observed location of a chordoma is in the sacrococcygeal region ( 50 to 55% ) followed by the cranio occipital region ( 25 to 30% )We present a case of a 30 years old lady who came to us with complaints of difficulty in walking and inability to hold objects in both hands.
Seven days later, the routine pathology affirmed that the morphological appearance was in accordance with the chordoma [Figure 1]f.
Primary mesothelioma, malignant nerve sheath tumors and involvement from primary vertebral tumors such as chondrosarcoma or chordoma are also rarely seen involving the brachial plexus.
The differential diagnosis of a clival lesion includes malignancy, infection, meningioma, and chordoma.