chordoma


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chordoma

 [kor-do´mah]
a malignant tumor arising in the axial skeleton from embryonic remains of the notochord.

chor·do·ma

(kōr-dō'mă), [MIM*215400]
A rare neoplasm of skeletal tissue in adults, derived from persistent portions of the notochord; composed of cells arranged in lobules, with abundant myxoid stroma; some cells contain vacuoles that resemble soap bubbles (physaliphorous cells); most frequently in the region of the clivus or lumbar-sacral cord.
[(noto)chord + G. -oma, tumor]

chordoma

An encapsulated, locally invasive malignant tumour that arises from the foetal notochord in the sacrococcygeal and sphenooccipital regions.
 
Epidemiology
Predominantly in older (age 50–70) men for sacrococcygeal region and age 20–40 for sphenooccipital chordoma.
 
Management
Surgery, RT.
 
Prognosis
Recurrence is common, often years after adequate therapy.

chor·do·ma

(kōr-dō'mă)
A rare neoplasm of skeletal tissue in adults, derived from persistent portions of the notochord.
[(noto)chord + G. -oma, tumor]

chordoma

A slow-growing tumour of the spine arising from remnants of the primitive NOTOCHORD. Chordomas rarely spread remotely, but can cause severe local damage.
References in periodicals archive ?
According to researchers, existing drugs could help chordoma patients.
Chordoma: Current concepts, management, and future directions.
The 32-year-old, who worked as call centre team leader, was identified with chordoma in April last year after he underwent lip correction surgery in Bahrain.
Skin represents an unusual site of onset for chordoma metastasis [7], occurring by direct extension, local recurrence, and metastasis.
Histological examination showed the following: 5 cases of malignant peripheral nerve sheath tumor, 4 cases of undifferentiated pleomorphic sarcoma, 3 cases of osteosarcoma and chondrosarcoma, 2 cases of chordoma, giant cell tumors of bone, and leiomyosarcoma, and 1 case each of malignant solitary fibrous tumor, malignant myoepithelioma, plasmacytoma, malignant lymphoma, histiocytic sarcoma, and hemangiopericytoma.
"We herein report an exceptional case of extra-axial dedifferentiated chordoma confirmed by the expression of brachyury, the first case report of this kind," reported surgical pathologist Dr.
Chordoid meningiomas often contain regions that are histologically similar to chordoma, with cords or trabeculae of eosinophilic, vacuolated cells in a background of abundant mucoid matrix background.
A BUDDING painter at age four, Aedan Pio Titco Pascual urgently needs an operation to get rid of chordoma, a rare type of cancer, growing inside his brain.