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The microscopic differential diagnosis includes chondrosarcoma, signet cell adenocarcinoma of the rectum, myxopapillary ependymoma, and chordoid meningioma.
EMA positive and pan CK negative in chordoid meningioma.
Chordoid meningioma arising in the pineal region: a case report.
Currently, a chordoid meningioma is considered to be a "meningioma variant consisting predominantly of tissue histologically similar to chordoma.
Chordoid meningioma, an uncommon variant of meningioma: a clinicopathologic study of 12 cases.
Within the meningeal neoplasm group, the most unusual cases were the sclerosing meningioma (patient 24; Figure 2, C) and the chordoid meningioma (patient 25; Figure 2, D) invading nerve, although the hemangiopericytoma (Figure 2, E), which had been mistaken for a possible schwannoma (Table), also showed small, neurofilament-positive nerve fibers buried deep with the lesion (patient 26; Figure 2, F).
Both of the invasive meningiomas, that is, the chordoid meningioma and the sclerosing meningioma, are known to be aggressive variants, although currently a WHO grade has not been assigned to sclerosing meningioma.
Chordoid meningiomas often contain regions that are histologically similar to chordoma, with cords or trabeculae of eosinophilic, vacuolated cells in a background of abundant mucoid matrix background.
Some of the more significant changes affecting tumor grade include classifying (1) meningiomas showing central nervous system invasion as grade II rather than grade III, (2) meningiomas with 4 or more mitotic figures per 10 high-power fields (HPFs) as grade II, (3) clear cell and chordoid meningiomas as grade II, (4) papillary and rhabdoid meningiomas as grade III, and (5) tumors with 20 or more mitotic figures per 10 HPFs as grade III.