chorangiosis

chorangiosis

A diffuse multifocal foeto-vascular defect, defined as the presence of 10 areas in the placenta with 10 microscopic fields containing 10 villi with 10 capillary lumens. The significance of chorangiosis as an independent prognostic factor of adverse pregnancy outcome is uncertain, but it is thought to increase foetal morbidity and mortality.
Mentioned in ?
References in periodicals archive ?
Placental tissues were available from 4 neonates; common findings were fibrinoid necrosis, chorangiosis, and amnion hyperplasia.
The proposed diagnostic scheme is easily applicable to routine diagnostics, but, quite surprisingly, we did not find any comment on chorangiosis and only a little advice about clinicopathologic correlation.
This adaptive angiogenesis is manifest as chorangiosis (Figure 2), a common feature of tobacco-exposed placentas (Pfarrer et al.
Results: Heavy placentae with abundant villous immaturity, chorangiosis and syncytial knots in group B and fibrinoid necrosis and calcification in group C were seen.
Additional features that were noted on histology in the HIV-positive group included evidence of meconium exposure (n=10), focal infarct (n=1), focal decidual vasculopathy (n=1), dysmaturity (n=3), fetal thrombotic vasculopathy (n=1), chorangiosis (n=1), intervillous thrombus (n=2) and intervillous haemorrhage (n=3); and in the HIV-negative group, infarcts (n=2), decidual vasculopathy (n=1) and dysmaturity (n=2).
2) In one large study chorangiosis occurred in 3% of 1614 deliveries and was associated with placental lesions including infarcts, chronic villitis, fetal artery thrombi, and spiral artery thrombi.
Examination of the placenta showed focal basal decidual inflammation, mild chorangiosis, and villus dys-maturity.
6) In heterogeneously hypermature placenta of the uterine (uteroplacental) pattern of placental injury, one may find focal chorangiosis if the Altshuler numerical criteria (2) are met.
1,21,22) Capillary profiles can be highlighted by endothelial markers, for example, CD34, to facilitate counting; however, for the diagnosis of chorangiosis, the cutoff point of 20 lumens, instead of 10 lumens, on hematoxylin-eosin slide (23) should be used as more vascular lumens are seen by immunohistochemistry.